Ampicillin Capsules

It is a broad-spectrum antibiotic. Its antibacterial effect on most G bacteria is not as good as penicillin G, but it is more effective than penicillin on negative bacteria. Its mechanism of action is the same as penicillin. However, enterococci are more sensitive to this product, and its effect on G-bacteria is weaker than kanamycin and gentamicin, and similar to tetracycline. It has a stronger antibacterial effect on Salmonella typhi and Escherichia coli, while Pseudomonas aeruginosa and Staphylococcus aureus are resistant to this product. It is mainly used to treat sepsis, urinary tract infection, lung infection, biliary tract infection, etc. caused by sensitive bacteria; its efficacy in treating typhoid and paratyphoid is similar to that of chloramphenicol. This product has a higher concentration in cerebrospinal fluid during meningitis, and is also suitable for treating meningitis caused by pneumococcus, meningococcus and influenza bacillus. Combining it with other semi-synthetic penicillins, aminoglycosides and chloramphenicol can enhance the efficacy.

The molecular formula is C16H18N3O4S, the molecular weight is 371.39, and the CASN is 69-52-3

This product is a clear injection.

It is mainly used to treat sepsis, urinary tract infection, lung infection, bile tract infection, etc. caused by sensitive bacteria; its efficacy in treating typhoid and paratyphoid is similar to that of chloramphenicol.

Oral administration: 0.25-0.75 g for adults, 4 times a day; the daily dose for children is 25 mg/kg based on body weight, 2-4 times a day.

1. It has cross-allergic reaction with penicillin, and various allergic reactions including anaphylactic shock may occur; 2. It has nausea, mild diarrhea and rash. Patients with severe renal damage and heart failure can induce heart failure by intravenous infusion of sodium salt of this product, so it is advisable to pay attention; 3. The rash reaction of this product is higher than that of other penicillin antibiotics; 4. Antibiotic-associated enteritis: The incidence of diarrhea is about 5%; 5. Increased SGOT; 6. Other reactions such as convulsions and blood system abnormalities may occur in large doses.

Patients with infectious mononucleosis, cytomegalovirus infection, lymphocytic leukemia, lymphoma, etc. are prone to rash when using this product.

Precautions for children: It is forbidden to use in children under 2 years old. Precautions for pregnancy and lactation: There are no strict controlled trials for the use of ampicillin in pregnant women, so pregnant women should use this product only when it is necessary. A small amount of ampicillin can be secreted from breast milk, so breastfeeding should be suspended when breastfeeding women take the drug. Precautions for the elderly: Due to the decline of physiological renal function, the dosage should be appropriately reduced.

1. Used in combination with probenecid, the blood concentration of this product can be increased. 2. Used in combination with cephalosporins and other drugs, it has a good synergistic effect on infections caused by enzyme-resistant Staphylococcus aureus, but it cannot be placed in the same container. 3. It cannot be used in combination with vitamins C and B. 4. Stability is reduced by the presence of glucose and fructose, so 0.9% N.S is best.

Keep away from light and store in airtight storage.

0.25g (calculated based on C16H19N3O4 tablets)

3 years