Tegafur Suppository
Function and Efficacy
This product is a derivative of fluorouracil. It is activated by the liver in the body and gradually converted into fluorouracil to play an anti-tumor role. It can interfere with and block the synthesis of DNA, RNA and protein, and mainly acts on the S phase. It is a cell cycle-specific drug of the anti-pyrimidine class. Its mechanism of action, efficacy and anti-tumor spectrum are similar to those of fluorouracil, but it has a long-lasting effect, good absorption and low toxicity. The chemotherapy index is twice that of fluorouracil, and the toxicity is only 1/4 to 1/7 of that of fluorouracil. No serious bone marrow suppression was observed in the chronic toxicity experiment, and the effect on immunity was relatively mild.
Ingredients
The main ingredient of this product is Tegafur, and its chemical name is: 1-(tetrahydro-2-furanyl)-5-fluoro-2,4(1H,3H)-pyrimidinedione. Its structural formula is: Molecular formula: C8H9FN2O3 Molecular weight: 200.17
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| TegafurIngredients |
This product is a derivative of fluorouracil. It is activated by the liver in the body and gradually converted into fluorouracil to play an anti-tumor role. It can interfere with and block the synthesis of DNA, RNA and protein, and mainly acts on the S phase. It is a cell cycle-specific drug of the anti-pyrimidine class. Its mechanism of action, efficacy and anti-tumor spectrum are similar to those of fluorouracil, but it has a long-lasting effect, good absorption and low toxicity. The chemotherapy index is twice that of fluorouracil, and the toxicity is only 1/4 to 1/7 of that of fluorouracil. No serious bone marrow suppression was observed in the chronic toxicity experiment, and the effect on immunity was relatively mild. More |
17902-23-7 | 10 |
Appearance
This product is an off-white or slightly yellow suppository.
Indication
Anti-tumor drug used for digestive tract tumors, breast cancer, bronchial lung cancer and liver cancer, etc.
Usage and Dosage
For rectal administration: 500 mg (1 tablet) at a time, 1 to 2 times a day.
Adverse Reactions
Bone marrow suppression reaction is mild, with a decrease in white blood cells and platelets. Neurotoxic reactions include headache, dizziness, ataxia, mental status changes, etc. A few patients experience nausea, vomiting, diarrhea, and changes in liver and kidney function. Fever, skin itching, and pigmentation are occasionally seen.
Precautions
1. Pregnant and lactating women are prohibited from using this product. 2. People who are allergic to this product are prohibited from using this product.
Special Population Medication
Precautions for children: This experiment has not been conducted and there is no reliable reference. Precautions for pregnancy and lactation: Pregnant and lactating women are prohibited. Precautions for the elderly: This experiment has not been conducted and there is no reliable reference.
Drug Interactions
This experiment has not been conducted and there are no reliable references.
Storage
Keep in a dark, airtight container in a cool place (not exceeding 20°C).
Packaging Specification
0.5 g
Validity Period
24 months
Manufacturer
Chengdu First Pharmaceutical Co., Ltd.
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Founded in:
2013-11-14 -
Address:
No. 133, Section 2, East Third Ring Road, Tianpeng Town, Pengzhou City, Sichuan Province -
Tax NO.:
91510182083307998R -
Registered Funds:
50 million yuan -
Website:
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Email: