Nitroglycerin solution

The main pharmacological action is to relax vascular smooth muscle. Nitroglycerin releases nitric oxide (NO), which is the same as endothelial relaxing factor, activating guanylate cyclase, increasing cyclic guanosine monophosphate (cGMP) in smooth muscle and other tissues, leading to dephosphorylation of myosin light chain, regulating the contractile state of smooth muscle, and causing vasodilation.

It is used for the treatment and prevention of angina pectoris caused by coronary heart disease, and can also be used to lower blood pressure or treat congestive heart failure.

Solution: 1% solution is administered sublingually, 0.05-0.1 ml at a time, 2 ml per day.

In the early stage of medication, nitrate-induced vasodilatory headache may occur, as well as facial flushing, dry mouth, dizziness, orthostatic hypotension and reflex tachycardia. Occasionally, blood pressure may drop significantly, bradycardia, angina pectoris may worsen and syncope may occur. Some patients may experience numbness in the oral mucosa.

It is contraindicated in patients with early myocardial infarction (with severe hypotension and tachycardia), severe anemia, glaucoma, increased intracranial pressure, and known allergy to nitroglycerin. It is also contraindicated in patients using sildenafil citrate (Viagra), which enhances the antihypertensive effect of nitroglycerin.

The blood pressure lowering effect of this class of drugs can be enhanced when used in combination with other vasodilators, calcium antagonists, beta-blockers, antihypertensive drugs, tricyclic antidepressants and alcohol. Care should be taken to avoid hypotension.

Keep in a dark, sealed and cool place

Beijing Yimin Pharmaceutical Co., Ltd.

• Founded in:

  1981-01-31

• Address:

  North of Yongjun Road, Shunyi District, Beijing

• Tax NO.:

  91110113102531398L

• Registered Funds:

  5.18 million yuan

• Website:

  Log in to view

• Email:

  Log in to view