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Compound Ketoconazole Cream

Function and Efficacy

Ketoconazole is an azole antifungal drug. It has antibacterial and bactericidal effects on dermatophytes, yeasts (Candida, Pityrosporum, Torulopsis, Cryptococcus), dimorphic fungi and Fungi; except for Entomophthora, it has weaker effects on Aspergillus, Schenckia, some Phaeochromocytaceae and Mucor. The mechanism of action of ketoconazole is mainly to highly selectively interfere with the activity of fungal cytochrome P-450, thereby inhibiting the biosynthesis of ergosterol on the fungal cell membrane. Clobetasol propionate is a potent topical corticosteroid. It acts quickly and has a strong capillary contraction effect. The anti-inflammatory effect is 112.5 times that of hydrocortisone, 2.3 times that of betamethasone sodium phosphate, and 18.7 times that of fluocinolone. Neomycin sulfate belongs to the aminoglycoside antibiotics and can be used externally to treat local infections.

Ingredients

This product is a compound preparation, the main components of which are ketoconazole, clobetasol propionate and neomycin sulfate.

Name Description Content CAS NO. Manufacturer
KetoconazoleIngredients

Azorrole antifungal drugs have antibacterial and bactericidal effects on dermatophytes, yeasts (Candida, Pityrosporum, Torulopsis, Cryptococcus), dimorphic fungi and fungi. The mechanism of action is to interfere with the activity of fungal cytochrome P-450, thereby inhibiting the biosynthesis of ergosterol on the fungal cell membrane.

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65277-42-1 25
Clobetasol propionateIngredients

A potent topical corticosteroid with a strong capillary constriction effect. Its anti-inflammatory effect is 112.5 times that of hydrocortisone, 2.3 times that of betamethasone sodium phosphate, and 18.7 times that of fluocinolone.

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25122-46-7 26
Neomycin sulfateIngredients

Aminoglycoside antibiotics, used externally to treat local infections.

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1405-10-3 10

Appearance

This product is a white or off-white cream with an emulsion base.

Indication

This product is mainly used for superficial fungal infections of the skin, such as tinea manuum, tinea pedis, tinea corporis, tinea cruris, etc.

Usage and Dosage

After cleaning, apply an appropriate amount evenly to the affected area. Twice a day. Treatment course: Generally, 2 weeks for tinea corporis and tinea cruris, and 4 weeks for tinea manuum and pedis.

Adverse Reactions

1. Common symptoms include erythema, burning, itching, tingling or other irritation, folliculitis, skin atrophy and thinning, capillary dilation, etc. 2. Dry skin, hirsutism, stretch marks, increased susceptibility to infection, etc. 3. Long-term use may cause hypercorticism, manifested as hirsutism, acne, moon face, osteoporosis, etc. 4. Occasionally may cause allergic contact dermatitis.

Precautions

It is contraindicated for patients who are allergic to the ingredients of this product, other azoles, aminoglycosides and corticosteroids.

Special Population Medication

Precautions for children: Children are prohibited from using this product. Precautions for pregnancy and lactation: 1. Pregnant women should use this product with caution after weighing the pros and cons. Long-term, large-area or large-scale use of this product is prohibited. 2. Lactating women should use this product with caution after weighing the pros and cons. Precautions for the elderly: Not yet clear.

Drug Interactions

1. Pregnant women should use this product with caution after weighing the pros and cons. Long-term, large-area or large-scale use of this product is prohibited. 2. Lactating women should use this product with caution after weighing the pros and cons.

Storage

Keep tightly closed in a cool, dark place.

Packaging Specification

Compound

Validity Period

24 months

Manufacturer

Anhui Hongsanqi Pharmaceutical Co., Ltd.

  • Founded in:

    2002-08-16
  • Address:

    Jianshe Road, Economic and Technological Development Zone, Huainan City, Anhui Province
  • Tax NO.:

    913404007408914515
  • Registered Funds:

    15 million yuan
  • Website:

  • Email:

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