Flurbiprofen Axetil Injection
Function and Efficacy
This product consists of lipid microspheres and flurbiprofen axetil encapsulated therein. Flurbiprofen axetil is a prodrug of flurbiprofen and a non-steroidal anti-inflammatory analgesic. Lipomicrosphere preparations have the functions of targeting, controlled release, and shortening the onset time. The advantage of using it for postoperative analgesia is that it has no central nervous system inhibitory effect, does not affect the awakening of patients in anesthesia, and can be used immediately after surgery.
Ingredients
Flurbiprofen axetil
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| FLURBIPROFEN AXETILIngredients |
Flurbiprofen axetil is a prodrug of flurbiprofen and a nonsteroidal anti-inflammatory analgesic. Lipomicrosphere preparations have the functions of targeting, controlled release, and shortened onset time. The advantage of using it for postoperative analgesia is that it has no central nervous system inhibitory effect, does not affect the awakening of patients under anesthesia, and can be used immediately after surgery. More |
91503-79-6 | 23 |
Appearance
This product is a white emulsion, slightly sticky and has a specific odor.
Indication
Used to relieve postoperative pain and cancer pain.
Usage and Dosage
50 mg/time, 1-2 times/day, IV push or IV drip
Adverse Reactions
1. Severe adverse reactions: rare shock, acute renal failure, nephrotic syndrome, gastrointestinal bleeding, convulsions with impaired consciousness. 2. The following serious adverse reactions have also been observed in studies of other preparations of flurbiprofen: rare aplastic anemia, toxic epidermal necrolysis (Lyell syndrome), and exfoliative dermatitis. 3. General adverse reactions: (1) Injection site: injection site pain and subcutaneous bleeding are occasionally seen; (2) Digestive system: nausea, vomiting, elevated transaminase levels, diarrhea are occasionally seen, and gastrointestinal bleeding is rare; (3) Mental and nervous system: fever is sometimes seen, headache, fatigue, drowsiness, chills are occasionally seen; (4) Circulatory system: increased blood pressure and palpitations are occasionally seen; (5) Skin: allergic reactions such as itching and rash are occasionally seen; (6) Blood system:
Precautions
It is contraindicated for patients with severe peptic ulcer, severe blood disease, severe abnormalities of heart, liver and kidney function, severe hypertension, and a history of aspirin asthma.
Special Population Medication
Precautions for children: The safety of children's use has not been determined, so it is not suitable for children. Precautions for pregnancy and lactation: 1. The safety of use in pregnant women has not been established. Women who are pregnant or may become pregnant must use it when the benefits of treatment outweigh the risks; 2. Try not to use it in the late pregnancy (animal experiments have found that the use of the drug in rats in the late pregnancy can cause delayed delivery and constriction of the fetal ductus arteriosus); 3. Avoid breastfeeding during the use of this product (it may be transferred into breast milk). Precautions for the elderly: Be especially careful of adverse reactions in elderly patients, and start with a small dose and administer carefully.
Drug Interactions
This product may cause spasms when used in combination with third-generation quinolone antibiotics such as norfloxacin, lomefloxacin and enoxacin. In addition, this product also interacts with aspirin, dicoumarol and propranolol. Pay attention to adjusting the dose when used in combination.
Storage
Store in a sealed container at 0-20℃ to avoid freezing.
Packaging Specification
5ml:50mg
Validity Period
18 months