Zoledronic Acid for Injection
Function and Efficacy
The pharmacological action of zoledronic acid is mainly to inhibit bone resorption. Its mechanism of action is not fully understood and may be related to multiple effects. Zoledronic acid can inhibit osteoclast activity in vitro, induce osteoclast apoptosis, and block osteoclast absorption of mineralized bone and cartilage by binding to bone. Zoledronic acid can also inhibit the enhanced osteoclast activity and bone calcium release caused by various stimulating factors released by tumors.
Ingredients
The main ingredient of this product is zoledronic acid, and its chemical name is 2-(imidazol-1-yl)-1-hydroxyethane-1,1-diphosphonic acid monohydrate
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Zoledronic acidIngredients |
Inhibition of bone resorption may be related to multiple effects: it can inhibit osteoclast activity in vitro, induce osteoclast apoptosis, block osteoclast absorption of mineralized bone and cartilage by binding to bones, and inhibit the enhanced osteoclast activity and bone calcium release caused by various stimulating factors released by tumors. More |
118072-93-8 | 37 |
Appearance
This product is white freeze-dried block.
Indication
Bone pain caused by osteolytic bone metastases of malignant tumors.
Usage and Dosage
Intravenous drip. For adults, 4 mg each time, diluted with 100 ml 0.9% sodium chloride injection or 5% glucose injection, then intravenously dripped for no less than 15 minutes. Administer once every 3-4 weeks or as directed by a doctor.
Adverse Reactions
The most common adverse reaction of this product is fever. Other adverse reactions mainly include: fatigue, chest pain, leg edema, conjunctivitis, nausea, vomiting, constipation, diarrhea, abdominal pain, dysphagia, anorexia, hypotension, anemia, hypokalemia, hypomagnesemia, hypophosphatemia, hypocalcemia, granulocytopenia, thrombocytopenia, pancytopenia, bone pain, joint pain, muscle pain; kidney: increased serum creatinine value, etc. (related to the time of administration); the toxic and side effects of zoledronic acid are mostly mild and transient. In most cases, they will automatically disappear within 24 to 48 hours without special treatment.
Precautions
Patients who are allergic to this product and other bisphosphonates are contraindicated. It is not recommended for patients with severe renal insufficiency.
Special Population Medication
Precautions for children: The safety and effectiveness of this product in children have not been determined, and its use is not recommended. Precautions for pregnancy and lactation: It is not clear whether this product will be secreted into breast milk. Because this product can bind to bones for a long time, pregnant and lactating women are prohibited from using this product.
Drug Interactions
This product should be used with caution when used in combination with aminoglycosides, because aminoglycosides have a synergistic effect in lowering blood calcium and may prolong the duration of hypocalcemia; when used in combination with diuretics, it may increase the risk of hypocalcemia; when used in combination with thalidomide, it will increase the risk of renal dysfunction in patients with multiple myeloma.
Storage
Keep in a light-proof, airtight, cool place. Valid for 24 months.
Packaging Specification
4mg
Validity Period
12 months
Manufacturer
Nanjing Pharmaceutical FACTORY Co., Ltd.
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Founded in:
1991-07-11 -
Address:
No. 26, Xingang Avenue, Nanjing Economic and Technological Development Zone -
Tax NO.:
91320192134908655F -
Registered Funds:
200.8 million yuan -
Website:
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Email: