Doxifluridine Capsules

This product is one of the new fluorinated pyrimidine series drugs. As a prodrug of fluorouracil (5-FU), it is converted into free 5-FU by pyrimidine nucleoside phosphorylase in the body after taking it, thereby exerting its anti-tumor effect. Animal tumor experiments and clinical tests have proved that the content and activity of pyrimidine nucleoside phosphorylase in tumors are significantly higher than those in normal tissues. Therefore, the conversion rate of 5-FU in tumor tissues of this product is also significantly higher than that of normal tissues and organs, in order of cervical cancer, bladder cancer, breast cancer, colorectal cancer and gastric cancer. In particular, the concentration of 5-FU in colorectal, gastric and breast cancer tumor tissues is significantly higher than that in normal tissues and plasma, so it can selectively kill tumor cells while causing less damage to normal tissues. It affects DNA and RNA synthesis respectively, mainly acting in the S phase, and also affects cells in other proliferation phases.

Main ingredients: The chemical name of this product is: 5'-deoxy-5-fluorouridine. Molecular formula: C9H11FN2O5 Molecular weight: 246.2

This product is a capsule, and the contents are white powder.

This product is used to treat breast cancer, gastric cancer, colon cancer, rectal cancer, nasopharyngeal cancer, and cervical cancer.

Oral administration: 4-6 capsules (0.8-1.2g) per day, divided into 3-4 times. The dosage may be increased or decreased according to age and symptoms, or as directed by a doctor. When used with other anti-tumor drugs, please follow the doctor's advice.

1 Bone marrow suppression mainly includes leukopenia and thrombocytopenia, and occasionally pancytopenia; 2 Digestive system: nausea, vomiting, loss of appetite, sometimes abdominal pain, bloating, constipation, stomatitis, etc., occasionally gastric ulcer, glossitis, etc.; 3 Mental and nervous system: orientation or hearing disorders, occasionally walking or sensory disorders, extrapyramidal system symptoms, paralysis, urinary incontinence, etc. Occasionally, abnormal sense of smell; 4 Abnormal electrocardiogram, hair loss, pigmentation, urticaria, etc.

Patients who are allergic to this product or are receiving the antiviral drug Sorivudine are contraindicated.

Precautions for children: The safety of this product for infants and young children has not been determined, so it should be used with caution. Precautions for pregnancy and lactation: Because this product has teratogenic effects, it is contraindicated for use in pregnant and lactating women. Precautions for the elderly: The physiological functions of the elderly are generally low, so it should be used with caution.

When the antiviral drug Sorivudine is used in combination with this product or fluorouracil, it can hinder the metabolism of the latter, leading to increased concentrations in the blood, significant bone marrow suppression, and severe blood toxicity that can lead to death, so their combined use is strictly prohibited.

Keep tightly closed in a cool, dark and dry place.

200mgx50s

36 months