Triamterene Hydrochlorothiazide Tablets
Function and Efficacy
1. Effects of hydrochlorothiazide on water and electrolyte excretion (1) Diuretic effect: Increased excretion of ions such as sodium, potassium, chloride, and phosphorus in urine, while decreased excretion of calcium in urine. Inhibits the reabsorption of sodium chloride in the distal tubule proximal and proximal tubules, thereby increasing the Na-K exchange in the distal tubules and collecting ducts, and increasing K secretion. (2) Antihypertensive effect: In addition to the diuretic and sodium excretion effects, there may also be extrarenal mechanisms involved in antihypertensive effects. 2. Amiloride directly inhibits the Na-K exchange in the distal tubules and collecting ducts of the kidneys, thereby increasing the excretion of Na, Cl-, and water, and reducing the excretion of K. The combination of the two can enhance the antihypertensive effect and reduce the impact of K excretion.
Ingredients
This product is a compound preparation, and its components are: each tablet contains 50 mg of triamterene and 25 mg of hydrochlorothiazide.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| TriamtereneIngredients |
Directly inhibits Na-K exchange in the distal tubules and collecting ducts of the kidney, thereby increasing the excretion of Na, Cl-, and water, and reducing the excretion of K. Combination with hydrochlorothiazide can enhance the antihypertensive effect and reduce the effect of K excretion. More |
396-01-0 | 19 | |
| HydrochlorothiazideIngredients |
Urinary excretion of sodium, potassium, chloride, phosphorus and other ions increases, while urinary excretion of calcium decreases. It inhibits the reabsorption of sodium chloride in the distal tubule anterior segment and proximal tubule, thereby increasing the Na-K exchange in the distal tubule and collecting duct, and increasing K secretion. In addition to the diuretic and sodium excretion effects, there may be extrarenal mechanisms involved in lowering blood pressure. More |
58-93-5 | 54 |
Appearance
This product is a yellow tablet.
Indication
Applicable to: 1. Edema diseases: excrete excess sodium and water from the body, reduce extracellular fluid volume, and eliminate edema. Common diseases include congestive heart failure, ascites due to liver cirrhosis, nephrotic syndrome, acute and chronic nephritis edema, early chronic renal failure, sodium and water retention caused by adrenocortical hormone and estrogen treatment; 2. Hypertension: It can be used alone or in combination with other antihypertensive drugs, mainly for the treatment of primary hypertension; 3. Central or nephrogenic diabetes insipidus; 4. Nephrolithiasis: It is mainly used to prevent stones formed by calcium salt components.
Usage and Dosage
Oral administration. 1 tablet at a time, 2 times a day or as directed by your doctor.
Adverse Reactions
Skin rash, thrombocytopenic purpura, etc.
Precautions
1. Use with caution in patients with anuria or severe renal impairment; 2. Use with caution in patients with diabetes; 3. Use with caution in patients with hyperuricemia or a history of gout; 4. Use with caution in patients with severe liver damage; 5. Use with caution in patients with hypercalcemia; 6. Use with caution in patients with hyponatremia; 7. Use with caution in patients with lupus erythematosus; 8. Use with caution in patients with pancreatitis; 9. Use with caution in patients with sympathectomy; 10. Use with caution in infants with jaundice; 11. Use with caution in pregnant, postpartum and lactating women.
Special Population Medication
Precautions for children: Use with caution in infants with jaundice, as this drug can increase blood bilirubin. Precautions for pregnancy and lactation: Use with caution in pregnant women, parturients and lactating women. Precautions for the elderly: Elderly patients are more likely to suffer from renal impairment when using this drug.
Drug Interactions
1. Adrenocorticotropic hormone can reduce the diuretic effect of this drug. 2. Non-steroidal anti-inflammatory analgesics, especially indomethacin, can reduce the diuretic effect of this drug. 3. When used in combination with dopamine, the diuretic effect is enhanced. 4. When used in combination with antihypertensive drugs, both the diuretic and antihypertensive effects are enhanced. 5. It can increase blood sugar. When used in combination with hypoglycemic drugs, the latter's dose should be appropriately increased.
Storage
Keep away from light and store in sealed container.
Packaging Specification
Triamterene 50mg, Hydrochlorothiazide 25mg
Validity Period
Tentative 24 months
Manufacturer
Tianjin Lisheng Pharmaceutical Co., Ltd.
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Founded in:
1981-06-17 -
Address:
No. 16, Saida North 1st Road, Xiqing Economic Development Zone, Tianjin -
Tax NO.:
91120000103069502J -
Registered Funds:
257.942988 yuan -
Website:
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Email: