Azasetron Hydrochloride Injection
Function and Efficacy
Pharmacological action: Azasetron hydrochloride is a selective 5-HT3 receptor antagonist, which has a significant inhibitory effect on nausea and vomiting caused by anticancer drugs such as cisplatin. Animal studies have shown that the affinity of azasetron hydrochloride for the 5-HT3 receptor in the rat cerebral cortex is about 410 times stronger than that of metoclopramide, twice that of ondansetron, and basically the same as granisetron. Toxicological studies: Repeated dose toxicity: This product was administered intravenously to rats, and the animals in the 10mg/kg and 60mg/kg groups showed an increase in food intake and weight, and a reversible increase in the weight of the heart, liver, brain and adrenal glands. Dogs were given continuous intravenous administration for 3 months, and when the dose reached 30mg/kg, symptoms such as vomiting and salivation occurred immediately after administration. Reproductive toxicity: Pre-pregnancy in rats
Ingredients
The main ingredient of this product is azasetron hydrochloride
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| AZASETRON HYDROCHLORIDEIngredients |
Azasetron hydrochloride is a selective 5-HT3 receptor antagonist, which has a significant inhibitory effect on nausea and vomiting caused by anticancer drugs such as cisplatin. Animal studies have shown that the affinity of azasetron hydrochloride for the 5-HT3 receptor in the rat cerebral cortex is about 410 times stronger than that of metoclopramide, twice that of ondansetron, and basically the same as that of granisetron. More |
141922-90-9 | 7 |
Indication
Used for vomiting caused by radiotherapy with cytotoxic drugs.
Usage and Dosage
10 mg once a day (1 vial at a time), diluted with 40 ml of normal saline, slowly injected intravenously 30 minutes before chemotherapy.
Adverse Reactions
Some patients experience thirst, constipation, headache, dizziness, abdominal discomfort, etc. The above reactions are mild and do not require special treatment. In severe cases, there have been reports of anaphylactic shock. Therefore, the patient's reaction should be closely observed during use. If abnormalities occur, the drug should be discontinued immediately and appropriate treatment should be given.
Precautions
1. Patients who are allergic to this type of drug (5-HT3 receptor blocker) and this product are contraindicated; 2. Patients with gastrointestinal obstruction are contraindicated.
Drug Interactions
1. This product will become turbid or crystallize when used with alkaline injection (such as furosemide, methotrexate, fluorouracil, piretanide, etc.) or etoposide injection, so it is necessary to dilute this product with sodium chloride injection before using it with the above alkaline drugs. 2. This product may reduce the content of this product when used with etoposide injection or fluoxetine sodium injection, so it should be used within 6 hours after preparation. 3. This product will become turbid or produce precipitation when used with diazepam injection, so it should be avoided to use it with them.
Storage
Keep in a dark place and sealed. The validity period is tentatively set at one year.
Packaging Specification
2ml:10mg
Manufacturer
Nanjing Chia Tai-tianqing Pharmaceutical Co., Ltd.
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Founded in:
2001-08-31 -
Address:
No. 9 Huiou Road, Nanjing Economic and Technological Development Zone -
Tax NO.:
91320100730586189T -
Registered Funds:
336.031726 yuan -
Website:
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Email: