Podophyllotoxin tincture
Function and Efficacy
In vitro and in vivo tests have proven that this product has anti-tumor activity, can inhibit microtubule polymerization, inhibit nuclear mitosis, and stop it in the middle stage. This product is not easily absorbed orally and has serious toxic and side effects, so its systemic application is limited. In vitro efficacy tests for topical treatment of condyloma acuminatum have proven that this product can inhibit the incorporation of deoxynucleoside and DNA synthesis in cultured normal human skin keratinocytes and cervical cancer epithelial cells, hindering their division and proliferation. After external application of this product, it can inhibit the division and proliferation of epithelial cells with warty proliferation caused by human papillomavirus (HPV) infection, causing necrosis and shedding, thereby playing a role in treating condyloma acuminatum.
Ingredients
Main ingredients and chemical names of this product: This product is a lignin anti-tumor ingredient extracted from plants of the genus Podophyllum in the family Botrytis. Its chemical name is [5R-(5alpha;,5alpha;beta;,8aalpha;,9alpha;)],5,8,8alpha;,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furan (3,4:6,7) naphtho-[2,3-d]-1,3-dioxetane-6(5alpha;H)-one. Molecular formula: C22H22O8 Molecular weight: 414.41
Appearance
This product is a colorless clear solution with an ethanol odor.
Indication
Used for condyloma acuminatum on the external genitalia and around the anus of men and women.
Usage and Dosage
1. Before applying the medicine, clean the affected area with a disinfectant and astringent solution (such as potassium permanganate solution, etc.) and wipe it dry; 2. Use a special medicine swab to apply the liquid medicine to the wart, apply it all over the wart, no need to repeat and try to avoid the liquid medicine from contacting normal skin and mucous membranes; 3. The total amount of medicine should not exceed 1 ml. After applying the medicine, expose the affected area to let the liquid medicine dry; 4. Apply the medicine twice a day for 3 consecutive days, and stop the medicine for 4 days for observation as a course of treatment. If there are still residual lesions, you can repeat a course of treatment, but no more than three courses of treatment.
Adverse Reactions
1 Most patients may experience varying degrees of burning or tingling sensations, erythema, edema and erosion at the site of application after medication; 2 Erythema or superficial erosion may occur locally after shedding. These are common local reactions and do not require medication discontinuation. 3 Some patients may have severe local reactions and may be treated with anti-inflammatory and astringent cold compresses or creams, lotions and pastes, which can quickly and significantly alleviate symptoms. For those with severe local ulcers, edema and severe pain, treatment may be stopped if necessary. 4 A small number of patients did not experience any adverse reactions during treatment. 5 No systemic adverse reactions were observed with topical treatment.
Precautions
It is contraindicated for patients who are allergic to this drug and for patients with unhealed wounds after surgery.
Special Population Medication
Precautions for children: There is currently a lack of experimental data on the use of the drug in children, and it is recommended that the drug should not be used in children. Precautions for pregnancy and lactation: It is forbidden for breastfeeding women. Precautions for the elderly: It has not yet been determined.
Drug Interactions
Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Storage
Keep away from light and store in sealed container.
Packaging Specification
3ml:15mg
Validity Period
24 months.