Amlodipine Besylate Dropping Pills

Pharmacological action: This product is a calcium ion antagonist or slow channel blocker. The contraction of myocardial and smooth muscle depends on the entry of extracellular calcium ions into cells through specific ion channels. This product selectively inhibits the transmembrane entry of calcium ions into smooth muscle cells and myocardial cells, and has a greater effect on smooth muscle than on myocardium. Its interaction with calcium channels is determined by the progressive rate of its binding and dissociation with receptor sites, so the pharmacological effect is gradually produced. This product is a peripheral artery dilator that acts directly on vascular smooth muscle, reduces peripheral vascular resistance, and thus lowers blood pressure.

Amlodipine besylate. Molecular weight: C20H25N2O5Cl·C6H6O3S

This product is white to light yellow pills.

1. Hypertension. This product can be used alone or in combination with other antihypertensive drugs. 2. Chronic stable angina pectoris and variant angina pectoris. This product can be used alone or in combination with other antianginal drugs.

Adults, oral or sublingual. 2.5mg~5mg/time, once/day. It can be increased to 10mg (2 pills) according to clinical efficacy. Generally, no dosage adjustment is required when used in combination with thiazide diuretics, beta-blockers and angiotensin converting enzyme inhibitors.

The most common adverse reactions are headache and edema. The dose-related adverse reactions with an incidence of 1% are as follows: edema, dizziness, hot flashes, and palpitations. The dose relationship is unclear, but the adverse reactions with an incidence of more than 1.0% are as follows: headache, fatigue, nausea, abdominal pain, and drowsiness. Among the above adverse reactions, the incidence of edema, hot flashes, palpitations, and drowsiness in women is higher than that in men.

Patients who are allergic to dihydropyridines or any of the ingredients in this product are contraindicated.

Precautions for children: The safety and effectiveness for children have not been determined. Precautions for pregnancy and lactation: There is a lack of research data on the use of this drug in pregnant women, but according to the results of animal tests, this product can only be used in pregnant women when it is absolutely necessary. It is not yet known whether this product can be secreted through breast milk. Lactating women who take this drug should stop breastfeeding. Precautions for the elderly: Clinical studies have not confirmed that the elderly react to this drug differently from young people, but considering that the elderly often have decreased liver, kidney and heart function, and are accompanied by other diseases and corresponding drug treatments, the lower limit of the dosage range is generally used for initial medication. The clearance rate of this product is reduced in the elderly, and the drug-time curve (AUC) increases by about 40%-60%, so a lower initial dose is also required.

1. Cimetidine, grapefruit juice, acidogens: The pharmacokinetics of this product are not changed when used together. 2. Atorvastatin, digoxin, ethanol: This product does not affect their pharmacokinetics. 3. Sildenafil: A single dose of Sildenafil (Viagra) in patients with primary hypertension has no effect on the pharmacokinetics of this product. The two drugs produce an independent antihypertensive effect when used together. 4. Warfarin: This product does not change the prothrombin action time of warfarin.

Seal and store in a cool place.

5mg (calculated as amlodipine)

36 months

Beijing Jiulong Pharmaceutical Co., Ltd.

• Founded in:

  1988-04-13

• Address:

  Yanqing Economic and Technological Development Zone, Yanqing District, Beijing

• Tax NO.:

  91110229103037287T

• Registered Funds:

  20.4 million yuan

• Email:

  Log in to view