Adapalene gel

Adapalene is a retinoid compound that has been shown to have anti-inflammatory properties in in vivo and in vitro inflammatory models. The chemical structure of adapalene is stable and is not easily decomposed in air and light. In terms of mechanism of action, adapalene binds to specific retinoic acid nuclear receptors like retinoic acid, but unlike retinoic acid, adapalene does not bind to protein-bound cytoplasmic receptors. In skin drug trials conducted in animal models established in mice, it was shown that adapalene can treat acne and also has effects on common acne and differentiation processes. The mechanism of action of adapalene is believed to be to reduce the formation of microacne by normalizing the differentiation of hair cells on hair follicles. In standard anti-inflammatory assays in vivo and in vitro, adapalene is superior to retinoic acid. It can inhibit the chemotactic reaction of human polymorphonuclear leukocytes and inhibit the metabolism of polymorphonuclear cells by inhibiting the conversion of arachidonic acid into inflammatory mediators through lipid oxidation. This shows that adapalene can inhibit inflammatory reactions mediated by cell reactions. Human clinical trials have shown that adapalene can relieve the inflammatory white reaction (such as pustules) of acne.

Laconutin hydrobromide. Chemical name: (1α,14α,16β)-20-ethyl-1,14,16-trimethoxyaconitane-4,8,9-triol 4-[2-(acetylamino)benzoate hydrobromide.

This product is white translucent gel.

This product is suitable for the treatment of common acne with acne, papules and pustules as the main manifestations. It can also be used to treat acne on the face, chest and back.

Gently squeeze the bottom of the medicine tube to squeeze enough medicine onto your fingertips to apply to the affected area, then tighten the cap.

The main adverse reaction that may occur is skin irritation, which can be reversed by reducing the frequency of medication or stopping the medication.

It is contraindicated for those who are allergic to this product.

Precautions for children: Its safety and effectiveness in pediatric patients under 12 years of age have not been established. Precautions for pregnancy and lactation: There are currently no reports on the efficacy of this product in pregnant women. It is recommended not to use this product during pregnancy. It is currently unknown whether this product is secreted in breast milk. Because many drugs are secreted in breast milk, it is recommended that lactating women use caution if they must use this product and do not apply it to the chest. Precautions for the elderly: In clinical trials, the subjects were aged between 12 and 30 years old, so it is not clear whether there is a difference between the elderly over 65 and the young.

So far, no interaction has been found between this product and other drugs that may be used on the skin at the same time. However, other retinoids or other drugs with similar mechanisms of action should not be used at the same time. The chemical structure of adapalene is stable and is not easily decomposed in air and sunlight. Extensive animal and human studies have not found phototoxicity and photosensitivity. However, the safety of adapalene for animals and humans when repeatedly exposed to sunlight or ultraviolet radiation is not yet known. Excessive sun exposure and ultraviolet radiation should be avoided when using this product. Adapalene has very low transdermal absorption, so it is impossible to interact with systemic drugs. There is no evidence that the efficacy of oral drugs such as contraceptives and antibiotics will be affected by the use of Differin on the skin. Differin may have a slight local irritation effect, and when used with peeling agents, astringents or irritants, it may cause additional irritation reactions. Therefore, using other anti-acne drugs for skin use such as erythromycin (concentration le; 4%), clindamycin phosphate (1%) solution or benzoyl peroxide aqueous gel (concentration le; 10%) in the morning and using Dafuwen gel at night can avoid the mutual degradation of drugs or the occurrence of cumulative irritation.

Keep sealed.

0.1% (30 g: 30 mg, calculated as C28H28O3)

Jiangsu Zhongdan Pharmaceutical Co., Ltd.

Jiangsu KOBAYASHI Pharmaceutical Co., Ltd.

• Founded in:

  2003-07-09

• Address:

  No. 8, Zhongdan Road, Hongqiao Town, Taixing City, Jiangsu Province

• Tax NO.:

  91321283752035302N

• Registered Funds:

  50 million yuan

• Website:

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