Nitrendipine Tablets

1This product is a dihydropyridine calcium channel blocker. 2This product inhibits the transmembrane calcium ion influx of vascular smooth muscle and myocardium, but its vascular action is mainly vascular, so its vascular selectivity is relatively strong. 3This product causes the dilation of systemic blood vessels such as coronary arteries and renal arterioles, producing a hypotensive effect.

Main ingredients: The main ingredients of this product and its chemical name are: 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid methyl ethyl ester. Molecular formula: C18H20N2O6 Molecular weight: 360.37

This product is light yellow tablet.

hypertension.

Common dosage for adults: Initially take 10 mg orally once a day, which can be adjusted to 20 mg twice a day depending on the situation.

Less common symptoms include headache and facial flushing. Less common symptoms include dizziness, nausea, hypotension, ankle edema, angina attack, and transient hypotension. People who are allergic to this product may develop allergic hepatitis, rash, and even exfoliative dermatitis.

It is contraindicated for patients who are allergic to this product or have severe aortic stenosis.

Precautions for children: Not clear yet. Precautions for pregnancy and lactation: The research on the use of this product in pregnant women is not sufficient, and the existing clinical application has not caused any problems, but attention should be paid to adverse reactions. Precautions for the elderly: The blood concentration of the drug is higher in the elderly, but the half-life is not prolonged, so the dose should be appropriately reduced; patients who are taking beta-receptor blockers should be cautious when adding this product. It is advisable to start with a small dose when combined with other drugs to prevent inducing or aggravating systemic hypotension, increasing the incidence of angina pectoris, heart failure, and even myocardial infarction. The recommended initial dose for elderly patients is 10 mg (1 tablet) per day.

1. The combination of y-receptor blockers and this drug can enhance the antihypertensive effect in most patients and reduce the tachycardia that occurs after the product lowers blood pressure; however, some patients may induce and aggravate systemic hypotension, heart failure and angina pectoris. 2. The combination of angiotensin-converting enzyme inhibitors is well tolerated and has a stronger antihypertensive effect. 3. The combination of long-acting nitrates is well tolerated, but there is still a lack of literature evaluating the effectiveness of this combination in controlling angina pectoris. 4. Some studies on digitalis suggest that taking this drug can increase the plasma concentration of digoxin in combination, with an average increase of 45%. Some studies believe that it does not increase the plasma concentration and toxicity of digoxin. It is suggested that we should monitor the blood concentration of digoxin when using it for the first time, adjusting the dose or stopping the use of nitrendipine to prevent digoxin overdose or underdose. 5. There are no reports that the combination of nitrendipine can increase the prothrombin time of coumarin anticoagulants. At present, the interaction between them cannot be confirmed. 6. Cimetidine: Since cimetidine can mediate the inhibition of liver cytochrome P450 enzymes and change the first-pass effect of nitrendipine, it is recommended that patients who are taking cimetidine should pay attention to the adjustment of drug dosage when taking nitrendipine in combination.

Keep in a light-proof and airtight container.

10mg

24 months.

Shanghai Sine Tianping Pharmaceutical Co., Ltd.

• Founded in:

  1998-05-07

• Address:

  No. 4598, Jindu Road, Minhang District, Shanghai

• Tax NO.:

  91310112832231856K

• Registered Funds:

  154.7 million yuan

• Email:

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