Artemether capsules
Function and Efficacy
Pharmacology Artemether is a derivative of artemisinin, which has a strong and rapid killing effect on the erythrocytic stage of malarial parasites and can quickly control clinical attacks and symptoms. The mechanism of action of artemisinin is not very clear, but it mainly interferes with the function of mitochondria, the surface membrane of malarial parasites. Artemisinin changes the membrane structure of malarial parasites by affecting the ultrastructure of the erythrocytic stage. Due to the effect on the food vesicle membrane, the nutritional intake of malarial parasites is blocked. When malarial parasites lose a large amount of cytoplasm and nutrients and cannot be replenished, they die quickly. Its mode of action is through its peroxide (dioxygen) bridge, mediated by the free iron produced after the decomposition of hemoglobin, to produce unstable organic free radicals and/or other electrophilic mediators, and then form covalent adducts with malarial parasite proteins, causing the death of malarial parasites. The antimalarial activity of artemether is 6 times greater than that of artemisinin. Toxicology The LD50 of artemether taken orally in mice is 895-977 mg/kg, and the LD50 of artemether oil injected intramuscularly in rats is 597 mg/kg. Subacute toxicity test showed that after intramuscular injection of artemether oil in rats at 18 mg/kg per day for 14 days, there were no other adverse reactions except for the decrease of reticulocyte count. This drug has certain embryotoxicity, which is manifested as embryo absorption.
Ingredients
Artemether, chemical name: (3R, 5S, 6R, 8S, 9R, 10S, 12R, 12R)-decahydro-10-methoxy-3, 6, 9-trimethyl-3, 12-oxo-12H-pyrano[4, 3-j-1, 2-benzodithipine. [Molecular formula] C16H26O5 [Molecular weight] 298.38
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| ArtemetherIngredients |
It has a strong and rapid killing effect on the erythrocytic stage of malarial parasites and can quickly control clinical attacks and symptoms. Its mechanism of action is mainly to interfere with the function of the mitochondria of the surface membrane of malarial parasites, affect the ultrastructure of the erythrocytic stage of malarial parasites, block the nutritional intake of malarial parasites, and cause their death. The mode of action is through its internal peroxide bridge, mediated by the free iron produced after the decomposition of hemoglobin, to produce unstable organic free radicals and/or other electrophilic mediators, forming covalent adducts with malarial parasite proteins, thereby killing malarial parasites. The antimalarial activity of artemether is 6 times greater than that of artemisinin. More |
71963-77-4 | 14 |
Appearance
This product is a capsule, and the contents are white powder.
Indication
It is suitable for the treatment of various types of malaria, including the treatment of chloroquine-resistant falciparum malaria, such as falciparum malaria and vivax malaria.
Usage and Dosage
Oral administration, once a day, 80-100 mg each time, for 7 consecutive days, double the first dose.
Adverse Reactions
This product has a mild reaction. Some patients may have a slight increase in aspartate aminotransferase and alanine aminotransferase, and a transient decrease in reticulocytes.
Precautions
It is contraindicated for those who are allergic to this product.
Special Population Medication
Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Use with caution in pregnant women. Precautions for the elderly: Please follow the doctor's advice.
Drug Interactions
Not yet clear.
Storage
Protect from light, seal tightly and store in a cool place.
Packaging Specification
100mg
Validity Period
24 months
Manufacturer
-
Founded in:
1995-12-14 -
Address:
No. 166, Keyi Road, High-tech Industrial Development Zone, Kunming, Yunnan Province -
Tax NO.:
91530000216562280W -
Registered Funds:
757.986969 yuan -
Website:
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Email: