Roxithromycin Tablets

This product is a semi-synthetic 14-membered macrolide antibiotic. Its antibacterial spectrum and antibacterial effect are basically similar to those of erythromycin. Its effect on Gram-positive bacteria is slightly worse than that of erythromycin. Its effect on Legionella pneumophila is stronger than that of erythromycin. Its antimicrobial effect on Chlamydia pneumoniae and Mycoplasma pneumoniae is similar to or slightly stronger than that of erythromycin. This product can penetrate the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor (P site), blocking the binding of transfer RNA (t-RNA) to the P site. It also blocks the transfer of the polypeptide chain from the acceptor site (A site) to the P site, thereby inhibiting bacterial protein synthesis.

The main ingredient of this product is roxithromycin. Chemical name: 9-{O-[(2-methoxyethoxy)-methyl]oxime}erythromycin.

This product is a film-coated tablet, which appears white or off-white after removing the coating.

This product is suitable for pharyngitis and tonsillitis caused by Streptococcus pyogenes, sinusitis, otitis media caused by sensitive bacteria, acute bronchitis, acute exacerbation of chronic bronchitis, pneumonia caused by Mycoplasma pneumoniae or Chlamydia pneumoniae; urethritis and cervicitis caused by Chlamydia trachomatis; skin and soft tissue infections caused by sensitive bacteria

Take orally on an empty stomach. The general course of treatment is 5 to 12 days. Adults can take 150 mg twice a day or 300 mg once a day. Children can take 2.5 to 5 mg/kg twice a day.

The main adverse reactions are gastrointestinal reactions such as abdominal pain, diarrhea, nausea and vomiting, but the incidence is significantly lower than that of erythromycin. Occasionally, there are rash, itching, dizziness, headache, abnormal liver function (elevated ALT and AST), decreased peripheral blood cells, etc.

This product is contraindicated in patients who are allergic to erythromycin or other macrolide drugs

Precautions for children: Not clear. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women. A dosage of less than 0.05% is excreted into breast milk. Although there are reports that it has little effect on infants, it is still necessary to consider whether to stop breastfeeding. Precautions for the elderly: If there is no significant change in pharmacokinetics in the elderly, there is no need to adjust the dose.

1. It should not be used in combination with ergotamine, dihydroergotamine, bromocriptine, terfenadine, ketoconazole and cisapride. 2. It has little effect on the metabolism of aminophylline and has little effect on carbamazepine, warfarin, ranitidine and other antacids.

Sealed, store in a dry place.

50mg

24 months

Shanghai Shyndec Pharmaceutical Co., Ltd.

• Founded in:

  1996-11-27

• Address:

  No. 378, Jianlu Road, Pudong New Area, Shanghai

• Tax NO.:

  91310000630459924R

• Registered Funds:

  1,341,172,692 yuan

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