Roxithromycin Tablets

This product is a semi-synthetic 14-membered macrolide antibiotic. The antibacterial spectrum and antibacterial effect are basically similar to those of erythromycin. It is slightly less effective than erythromycin against Gram-positive bacteria, and stronger than erythromycin against Legionella pneumophila. The antimicrobial effect against Chlamydia pneumoniae, Mycoplasma pneumoniae, and Ureaplasma urealyticum is similar to or slightly stronger than that of erythromycin. This product can penetrate the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor ("P" position), blocking the transfer RNA (t-RNA) binding to the "P" position, and also blocking the transfer of the polypeptide chain from the acceptor position ("A" position) to the "P" position, thereby inhibiting bacterial protein synthesis.

The main ingredient of this product is roxithromycin. Chemical name: 9-{O-[(2-methoxyethoxy)-methyl]oxime}erythromycin.

This product is a film-coated tablet, which appears white or off-white after removing the coating.

This product is suitable for pharyngitis and tonsillitis caused by Streptococcus pyogenes, sinusitis, otitis media, acute bronchitis, acute exacerbation of chronic bronchitis caused by sensitive bacteria, pneumonia caused by Mycoplasma pneumoniae or Chlamydia pneumoniae; urethritis and cervicitis caused by Chlamydia trachomatis; skin and soft tissue infections caused by sensitive bacteria.

Take orally on an empty stomach. The general course of treatment is 5 to 12 days. Adults can take 150 mg twice a day or 300 mg once a day. Children can take 2.5 to 5 mg/kg twice a day.

The main adverse reactions are gastrointestinal reactions such as abdominal pain, diarrhea, nausea, and vomiting, but the incidence is significantly lower than that of erythromycin. Occasionally, there are rash, itchy skin, dizziness, headache, abnormal liver function (increased ALT and AST), and decreased peripheral blood cells.

Patients who are allergic to this product, erythromycin or other macrolide drugs are contraindicated.

Precautions for children: Not clear. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women. A dosage of less than 0.05% is excreted into breast milk. Although there are reports that it has little effect on infants, it is still necessary to consider whether to stop breastfeeding. Precautions for the elderly: If there is no significant change in pharmacokinetics in the elderly, there is no need to adjust the dose.

1. It can be used in combination with ergotamine, dihydroergotamine, bromocriptine, terfenadine, ketoconazole and cisapride. 2. The metabolic effect of aminophylline is small, and it has little effect on carbamazepine, warfarin, ranitidine and other antacids.

Sealed, store in a dry place.

150mg

24 months

Shanghai Shyndec Pharmaceutical Co., Ltd.

• Founded in:

  1996-11-27

• Address:

  No. 378, Jianlu Road, Pudong New Area, Shanghai

• Tax NO.:

  91310000630459924R

• Registered Funds:

  1,341,172,692 yuan

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