Procaine Hydrochloride Injection

This product is an ester local anesthetic, which can temporarily block the conduction of nerve fibers and has an anesthetic effect. This product has weak penetration into the skin and mucous membranes and is not suitable for surface anesthesia. This product has poor diffusion and permeability. Its hydrochloride binding form releases free alkali in the tissue to exert local anesthetic effects. This product has a constant inhibition on the central nervous system and excessive excitement. First, it causes sedation and dizziness, and the pain threshold is increased, followed by vertigo, disorientation, and ataxia. The central inhibition continues to deepen, and there is a dull perception, confusion, and then a coma. If the dose continues to increase, symptoms of poisoning such as muscle tremor, irritability, and convulsions may occur. This product has the effect of exciting the sympathetic nerves in small doses, which accelerates the heart rate and blood pressure. If the dose is increased, the blood pressure drops and the heart rate increases due to myocardial inhibition, peripheral vasodilation, and mild ganglion blockade. This product inhibits the release of acetylcholine from the presynaptic membrane, produces a certain neuromuscular blockade, can enhance the effect of non-depolarizing muscle relaxants, and directly inhibits smooth muscles, which can relieve smooth muscle spasms.

This product is a sterile isotonic aqueous solution of procaine hydrochloride and sodium chloride. The content of procaine hydrochloride (C13H20N2O2.HCl) should be 95.0% to 105.0% of the labeled amount.

This product is sterilized white crystal or crystalline powder, odorless, slightly bitter and numbing.

Local anesthetics. Used for infiltration anesthesia, block anesthesia, lumbar anesthesia, epidural anesthesia and blockade therapy, etc.

Infiltration anesthesia: 0.25%-0.5% aqueous solution, no more than 1.5g per hour. Block anesthesia: 1%-2% aqueous solution, no more than 1.0g per hour. Epidural anesthesia: 2% aqueous solution, no more than 0.75g per hour.

This product may cause hypersensitivity reactions and allergic reactions. Some patients may develop methemoglobinemia. Excessive dosage, rapid absorption or accidental entry into blood vessels may cause toxic reactions.

It is contraindicated for patients with heart and kidney dysfunction, myasthenia gravis, etc.

1. It can enhance the effect of muscle relaxants and prolong the duration of action. When used in combination with muscle relaxants, the dosage of muscle relaxants should be reduced. 2. The dosage should be reduced when used in combination with other local anesthetics. 3. This product can reduce the efficacy of sulfonamides, so it is not suitable to use sulfonamides at the same time. 4. This product can enhance the effect of digitalis drugs, and combined use can lead to their toxic reactions. 5. Anticholinesterase drugs such as neostigmine can interfere with the metabolism of this product, making it more toxic, so it is forbidden to use it in combination. 6. This product can deepen the respiratory depression and hypotension caused by narcotic analgesics. 7. This product should not be used in combination with the following drugs: sodium bicarbonate, barbiturates, aminophylline, magnesium sulfate, heparin sodium, sodium nitroprusside, mannitol, neostigmine methylsulfate, hydrocortisone, dexamethasone, etc.

Keep away from light and store in a sealed container.

100 ml: 1 g

Sichuan Kelun Pharmaceutical Co., Ltd.

• Founded in:

  2002-05-29

• Address:

  South 2nd Road, Xindu Satellite City Industrial Development Zone, Chengdu

• Tax NO.:

  9151010020260067X4

• Registered Funds:

  1,601,497,373 yuan

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