Levofloxacin mesylate

This product has a broad-spectrum antibacterial effect and strong antibacterial effect. It has strong antibacterial activity against most Enterobacteriaceae, such as Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, and Gram-negative bacteria such as Haemophilus influenzae, Legionella pneumophila, and Neisseria gonorrhoeae. It also has antibacterial effects on Gram-positive bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, and Mycoplasma pneumoniae and Chlamydia pneumoniae, but has poor effects on anaerobic bacteria and enterococci. This product is the levorotatory form of ofloxacin, and its in vitro antibacterial activity is about twice that of ofloxacin. Its mechanism of action is to inhibit the activity of bacterial DNA gyrase, prevent the synthesis and replication of bacterial DNA, and cause bacterial death.

Levofloxacin mesylate.

Mainly used for acute and chronic bacterial infections of the respiratory, digestive, urinary, reproductive systems, skin and soft tissues, as well as surgery, otolaryngology, ophthalmology, and stomatology departments caused by sensitive bacteria

Oral. Common dosage for adults: 1. Bronchial infection, lung infection: 0.2g once, twice a day, or 0.1g once, 3 times a day, for a course of 7 to 14 days. 2. Acute simple lower urinary tract infection: 0.1g once, twice a day, for a course of 5 to 7 days; complicated urinary tract infection: 0.2g once, twice a day, or 0.1g once, 3 times a day, for a course of 10 to 14 days. 3. Bacterial prostatitis: 0.2g once, twice a day, for a course of 6 weeks. Common dosage for adults is 0.3 to 0.4g per day, divided into 2 to 3 times. If the infection is severe or the sensitivity of the pathogen is poor, such as Pseudomonas aeruginosa and other Pseudomonas bacterial infections, the therapeutic dose can also be increased to 0.6g per day, divided into 3 times.

1. Gastrointestinal reactions: abdominal discomfort or pain, diarrhea, nausea or vomiting. 2. Central nervous system reactions may include dizziness, headache, drowsiness or insomnia. 3. Allergic reactions: rash, skin itching, occasionally exudative erythema multiforme and angioneurotic edema. Photosensitivity reactions are less common. 4. Occasionally, the following may occur: (1) epileptic seizures, mental abnormalities, irritability, confusion, hallucinations, tremors. (2) interstitial nephritis manifestations such as hematuria, fever, and rash. (3) phlebitis. (4) crystalluria, which is more common when used in high doses. (5) joint pain. 5. A small number of patients may experience elevated serum aminotransferase, elevated blood urea nitrogen, and decreased peripheral white blood cells, which are mostly mild and transient.

1. Patients with a history of allergy to this product and ofloxacin are prohibited from using this product; 2. Patients with severe renal dysfunction should use this product with caution; 3. Patients with central nervous system diseases should use this product with caution; 4. Pregnant and lactating women should not use this product; 5. Patients under 18 years old should use this product with caution.

Precautions for children: Use with caution in patients under 18 years of age. Precautions for pregnancy and lactation: Contraindicated for pregnant and lactating women.

1. Urine alkalinizing agents can reduce the solubility of this product in urine, leading to crystalluria and nephrotoxicity. 2. When quinolone antibiotics are used in combination with theophylline, competitive inhibition of the cytochrome P450 binding site may lead to a significant reduction in the liver elimination of theophylline, a prolonged blood elimination half-life (t1/2?), an increase in blood drug concentration, and the appearance of symptoms of theophylline poisoning, such as nausea, vomiting, tremor, restlessness, excitement, convulsions, palpitations, etc. This product has little effect on the metabolism of theophylline, but the blood drug concentration of theophylline should still be measured and the dosage adjusted when used in combination. 3. When this product is used in combination with cyclosporine, the blood drug concentration of cyclosporine can be increased. The blood concentration of cyclosporine must be monitored and the dosage adjusted. 4. When this product is used in combination with the anticoagulant warfarin, although the anticoagulant effect of the latter is slightly enhanced, the patient's prothrombin time should also be closely monitored when used in combination. 5. Probenecid can reduce the secretion of this product from the renal tubules by about 50%. When used together, it may cause toxicity due to the increased blood concentration of this product. 6. This product can interfere with the metabolism of caffeine, thereby reducing the elimination of caffeine, prolonging the blood elimination half-life (t1/2beta;), and may cause central nervous system toxicity. 7. Acid-reducing drugs and iron preparations containing aluminum and magnesium can reduce the oral absorption of this product and should not be used together. 8. When this product is used in combination with the non-steroidal anti-inflammatory drug fenbufen, convulsions occasionally occur, so it is not suitable for use with fenbufen.

Keep away from light and store in sealed container.

Hainan Zhonghe Pharmaceutical Co., Ltd.

• Founded in:

  1995-04-17

• Address:

  No.168 Nanhai Avenue, Haikou City, Haikou Free Trade Zone

• Tax NO.:

  91460000293675844T

• Registered Funds:

  360 million yuan

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