Halcinonide solution

Efficacy of this product: 1. Anti-inflammatory effect. This product is a topical medication and a highly effective fluorinated and chlorinated corticosteroid with anti-inflammatory, anti-pruritic and vasoconstrictive effects. This product replaces the 21st hydroxyl group with a chlorine atom on the skeleton of triamcinolone. The anti-inflammatory potency multiple determined by the vasoconstriction test is 360. There is evidence that the intensity of the vasoconstriction test is consistent with the efficacy. Its anti-inflammatory and antipruritic mechanism of action is to increase the reactivity of β receptors to catecholamine, increase the production of CAMP by activating adenylate cyclase, and reduce the destruction of CAMP by inhibiting phosphoethylesterase, resulting in an increase in the annual concentration of cAMP in cells and inhibiting the release of histamine. The effect of this product in inhibiting the proliferation of granulomas in rats and mice is similar to that of dexamethasone. Mice induced by formaldehyde

The main ingredients of this product and their chemical names are: Halcinonide (clofosinolone, halcinonide), 16α, 17-[(1-methylethylidene)bis(oxy)]-11β-hydroxy-21-chloro-9-fluoropregnane-4-ene-3,20-dione.

This product is a colorless, clear, slightly viscous liquid.

This product is used for contact eczema, atopic dermatitis, neurodermatitis, small-area psoriasis, lichen sclerosus atrophicus, lichen planus, discoid lupus erythematosus, seborrheic dermatitis (non-facial) hypertrophic scars.

Apply to the affected area once in the morning and evening.

1. A small number of patients experience burning sensation, stinging, and temporary itching at the site of application. Long-term use may cause dilation of skin capillaries (especially on the face), skin atrophy, and atrophic striae (prone to adolescents). Skin atrophy may be followed by purpura, ecchymosis, skin fragility, hirsutism, folliculitis, miliary papules, skin depigmentation, and delayed ulcer healing. The packing method is prone to secondary fungal infection in skin folds. 2. When absorbed through the skin for a long time, systemic adverse reactions may occur (see precautions).

1. Those who are allergic to the drug. 2. Primary skin lesions caused by bacteria, fungi, viruses and parasites. 3. Ulcerative lesions. 4. Acne and rosacea. 5. Use on the eyelids (risk of causing glaucoma). 6. Exudative skin diseases. 7. Not suitable for use on the face.

Precautions for children: It should be applied on a small area and for a short period of time. Once the symptoms subside, stop the drug or switch to other drugs immediately. Children under one year old should not use this drug as much as possible. Precautions for pregnancy and lactation: There is no research on the teratogenic effect of topical drugs in humans. It should be used with caution during pregnancy. When a large amount of topical drugs are absorbed through the skin, they can be excreted in breast milk. Use with caution during lactation. Precautions for the elderly: This experiment has not been conducted and there is no reliable reference literature.

If you are using other medicines, you should consult your physician or pharmacist before using this product.

Store tightly closed at room temperature.

0.1%

36 months

Shandong Chenxin Fodu Pharmaceutical Co., Ltd.

• Founded in:

  2012-10-24

• Address:

  West side of the south end of Zhongdu Street, Wenshang County Economic Development Zone, Jining City, Shandong Province

• Tax NO.:

  91370830056218957G

• Registered Funds:

  108 million yuan

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