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Doxepin Hydrochloride Tablets

Function and Efficacy

This product is a tricyclic antidepressant. Its function is to inhibit the reuptake of 5-hydroxytryptamine and norepinephrine by the central nervous system, thereby increasing the concentration of these two neurotransmitters in the synaptic cleft and exerting an antidepressant effect. It also has antianxiety and sedative effects.

Ingredients

The main ingredients of this product are: doxepin hydrochloride, chemical name: N,N-dimethyl-3-dibenzo[b,e]-oxepin-11(6H)ylidene-1-propylamine hydrochloride, mixture of cis and trans isomers.

Name Description Content CAS NO. Manufacturer
Doxepin hydrochlorideIngredients

This product is a tricyclic antidepressant. Its function is to inhibit the reuptake of 5-hydroxytryptamine and norepinephrine by the central nervous system, thereby increasing the concentration of these two neurotransmitters in the synaptic cleft and exerting an antidepressant effect. It also has antianxiety and sedative effects.

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1229-29-4 18

Appearance

This product is a coated tablet, which appears white after removing the coating.

Indication

Used to treat depression and anxiety neurosis.

Usage and Dosage

Common oral dosage: 25 mg (1 tablet) at a time, 2-3 times a day, then gradually increase to a total of 100-250 mg (4-10 tablets) per day. High dose: no more than 300 mg (12 tablets) per day.

Adverse Reactions

In the early stage of treatment, drowsiness and anticholinergic reactions may occur, such as hyperhidrosis, dry mouth, tremor, dizziness, blurred vision, dysuria, constipation, etc. Other symptoms include rash, postural hypotension, and occasionally epileptic seizures, bone marrow suppression or toxic liver damage.

Precautions

Patients with severe heart disease, recent history of myocardial infarction, epilepsy, glaucoma, urinary retention, hyperthyroidism, liver damage, delirium, granulocytopenia, and allergy to tricyclic drugs.

Special Population Medication

Precautions for children: Use with caution. Precautions for pregnancy and lactation: Use with caution. Precautions for the elderly: Start with a small dose and reduce the dose according to the condition.

Drug Interactions

1. When this product is used in combination with sultopride, the risk of ventricular arrhythmias is increased, and in severe cases, torsades de pointes arrhythmia may occur. 2. When this product is used in combination with ethanol or other central nervous system depressants, the central nervous system depressant effect is enhanced. 3. When this product is used in combination with adrenaline and norepinephrine, it is easy to cause hypertension and arrhythmias. 4. When this product is used in combination with clonidine, the latter's antihypertensive effect is weakened. 5. When this product is used in combination with anticonvulsants, the effect of anticonvulsants may be reduced. 6. When this product is used in combination with fluoxetine or fluvoxamine, the plasma concentrations of both may be increased, resulting in convulsions and increased adverse reactions. 7. This product

Storage

Keep away from light and store in sealed container.

Packaging Specification

25mg (as doxepin)

Validity Period

36 months.

Manufacturer

Jiangsu Pingguang Pharmaceutical (Jiaozuo) Co., Ltd.

  • Founded in:

    2002-03-19
  • Address:

    300 meters north of the extension section of Jiefang Avenue, east of Huazhang Road, Fengxian Economic Development Zone
  • Tax NO.:

    91320321730727420F
  • Registered Funds:

    14.4522 million yuan
  • Email:

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