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Vemurafenib Pharmacy grade

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CAS No.:

918504-65-1

Grade:

Pharmaceutical Grade

Port:

Any China Port

Packaging:

5kg/2kg Cardboard Drum

Price valid (until):

2017-01-01

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Shandong Zhongke Taidou Chemical CO LTD

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Pitavastatin Calcium,6-Amino-1,3-dimethyluracil,Ethyl 2-amino-7-isopropyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylate,3-(3-Nitrophenyl)propionic acid,6-Amino-1-methyluracil,2,4-Dihydroxy-3-nitropyridine

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Product Description
Seller Information

Description

N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide Chemical Properties

density	1.46
form	White powder.
pka	6.26±0.10(Predicted)
CAS DataBase Reference	918504-65-1

Safety Information

HS Code

29339900

N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide Usage And Synthesis

Description

In August 2011, the United States FDA approved vemurafenib (PLX- 4032, RO-5185426) for the treatment of patients with metastatic melanoma with the BRAFV600E mutation. Vemurafenib has been developed as a targeted therapy for patients with the BRAF gene mutation since oncogenic B-raf signaling is implicated in approximately 50% of melanomas. Vemurafenib was identified based on an initial high-throughput screen followed by the extensive use of structure-based drug design. Vemurafenib is a potent inhibitor of B-RafV600E kinase (IC₅₀=13 nM) compared to its potency against wildtype B-raf (IC₅₀=160 nM) and is fairly selective versus a panel of 200 kinases. It does inhibit other kinases (RAF1, SRMS, ACK1, MAP4K5, and FGR) and mutant B-raf kinases (BRAFV600K, BRAFV600D, and BRAFV600R) with enzyme IC_50's of <100 nM.

Chemical Properties

Off-White Solid

Basic Info

Product Name:

Vemurafenib

Other Name:

1-Propanesulfonamide,N-[3-[[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-;N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide;Vemurafenib;Ro 51-85426;RG 7204;PLX 4032;Zelboraf;Propane-1-sulfonic acid [3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]amide;RO 5185426;1029872-54-5;1652573-83-5

CAS No.:

918504-65-1

Molecular Formula:

C23H18ClF2N3O3S

InChIKeys:

InChIKey=GPXBXXGIAQBQNI-UHFFFAOYSA-N

Molecular Weight:

489.9221264

Exact Mass:

489.92

UNII:

207SMY3FQT

NSC Number:

761431

DSSTox ID:

DTXSID50238710

NCI Thesaurus Code:

C64768

Color/Form:

White to off-white crystalline solid

ATC Code:

L01EC01|L01XE15|L - Antineoplastic and immunomodulating agents

HScode:

2935009090

Categories:

Antineoplastic Agents

Characteristics

PSA:

100

XLogP3:

Density:

1.46

Melting Point:

272°C

Flash Point:

384.0±35.7 °C

Refractive Index:

1.653

Water Solubility:

H2O: <1 mg/mL;Practically insoluble in aqueous media

Storage Conditions:

Store at room temperature 20 deg C - 25 degC (68 deg F - 77 deg F); excursions permitted between 15 deg C and 30 deg C (59 deg F and 86 deg F), See USP Controlled Room Temperature. Store in the original container with the lid tightly closed.

Vapor Pressure:

8.21X10-15 mm Hg at 25 deg C (est)

PKA:

7.1None

Henrys Law Constant:

Henry's Law constant = 1.23X10-17 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

7.1|pKa = 7.2 (amine) (est)

See More Vemurafenib Properties 

Hazard Identification

Classification of the substance or mixture

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H410 Very toxic to aquatic life with long lasting effects
Prevention	P273 Avoid release to the environment.
Response	P391 Collect spillage.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Vemurafenib Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Pitavastatin Calcium,6-Amino-1,3-dimethyluracil,Ethyl 2-amino-7-isopropyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylate,3-(3-Nitrophenyl)propionic acid,6-Amino-1-methyluracil,2,4-Dihydroxy-3-nitropyridine

Location:
No.592 Gangxing Road.High Tech Zone Jinan City Shandong Province China

Payment Terms:
D/P

Average lead Time:
60

Total Annual Revenue:
Less than $1 million

Shandong Zhongke Taidou Chemical Co., Ltd focuses on reseach, development and production of raw material medicine, intermediate medicine and fine chemical products. It is a combination of research, industrial operation and trading businesses. We have a team with high technology research caliber, cooperating with Shandong University, Lanzhou University and Tianjin Univisity. We also employ several famous professors to instruct the research and production for our company. In 2002, we established large scale production workshop, and owned several multi-functional production lines with large capacity. 70% of the products are used for export markets.
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