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Proparacaine hydrochloride, roxymetacaine hydrochloride, Proparacaine Hcl, Ophthain 99% white powder 5875-06-9 Senwayer

Name: Proparacaine hydrochloride, roxymetacaine hydrochloride, Proparacaine Hcl, Ophthain 99% white powder 5875-06-9 Senwayer
Brand: Senwayer
SKU: pr2203285104
Price: 220 USD
Availability: InStock

3 Inquiries

Unit Price: Get Latest Price 

CAS No.:

5875-06-9

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

Senwayer

Packaging:

500g/ bag 25kg/ drum

Sample Available:

Yes

Price valid (until):

2022-07-02

Contact Supplier

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Dingwang Technology (Wuhan) Co., Ltd.

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,L/C

Average Lead Time:

10 days

Qualification:

Main Products:

API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Proparacaine hydrochloride ophthalmic solution 0.5% is a topical local anesthetic for ophthalmic use. The active ingredient is represented by the structural formula:

Established name: Proparacaine Hydrochloride

Chemical name: Benzoic acid, 3-amino-4-propoxy-,2-(diethylamino) ethyl ester, monohydrochloride.

Product name	Proparacaine hydrochloride
CAS No.	5875-06-9
MF	C16H27ClN2O3
MW	330.85
EINECS No.	227-541-7
Melting point	182.0-183.3°
Storage	Inert atmosphere,Store in freezer, under -20°C

Dosage and Administration

Usual Dosage: Removal of foreign bodies and sutures, and for tonometry: 1 to 2 drops (in single instillations) in each eye before operating.

Short corneal and conjunctival procedures: 1 drop in each eye every 5 to 10 minutes for 5 to 7 doses.

NOTE: Proparacaine hydrochloride ophthalmic solution should be clear to straw-color. If the solution becomes darker, discard the solution.

Product Side Effect

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have severe burning, stinging, or irritation in your eyes after receiving proparacaine ophthalmic eyedrops.

Call your doctor at once if you have:

slow healing after eye surgery;
vision changes; or
a restless or nervous feeling followed by depression.

Common side effects may include:

eye redness or mild discomfort;
watery eyes; or
increased winking.

PRECAUTIONS

Carcinogenesis, Mutagenesis, Impairment of Fertility

Long-term studies in animals have not been performed to evaluate carcinogenic potential, mutagenicity, or possible impairment of fertility in males or females.

Pregnancy

Pregnancy Category C: Animal reproduction studies have not been conducted with proparacaine hydrochloride ophthalmic solution 0.5%. It is also not known whether proparacaine hydrochloride can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Proparacaine hydrochloride should be administered to a pregnant woman only if clearly needed.

Nursing Mothers

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when proparacaine hydrochloride is administered to a nursing woman.

Pediatric Use

Safety and effectiveness of proparacaine hydrochloride ophthalmic solution in pediatric patients have been established. Use of proparacaine hydrochloride is supported by evidence from adequate and well-controlled studies in adults and children over the age of twelve, and safety information in neonates and other pediatric patients.

Geriatric Use

No overall clinical differences in safety or effectiveness have been observed between the elderly and other adult patients

ECHEMI Editorial Reference

Proparacaine Hydrochloride is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.IC50 Value: 3.4 mM(ED50) [1]Target: Sodium Channelin vitro: Proparacaine is more potent and less toxic than cocaine [1]. Proparacaine significantly increases in FHV-1 (P < 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used [2].in vivo: Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton [3]. Proparacaine acts like bupivacaine
Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, and resulting in a loss of sensation.

Basic Info

Product Name:

Proparacaine hydrochloride

Other Name:

Benzoic acid,3-amino-4-propoxy-,2-(diethylamino)ethyl ester,hydrochloride (1:1);Benzoic acid,3-amino-4-propoxy-,2-(diethylamino)ethyl ester,monohydrochloride;2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride;Ophthaine hydrochloride;Proparacaine hydrochloride;2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate monohydrochloride;Ophthain;Alcaine;Chibro-keracaine;Ophthetic;Fluoracaine;Ak-Taine;Paracaine

CAS No.:

5875-06-9

Molecular Formula:

C16H26N2O3.ClH

InChIKeys:

InChIKey=BFUUJUGQJUTPAF-UHFFFAOYSA-N

Molecular Weight:

330.85

Exact Mass:

330.171021

EC Number:

227-541-7

UNII:

U96OL57GOY

NSC Number:

759896

DSSTox ID:

DTXSID0049022

NCI Thesaurus Code:

C47693

HScode:

2922504500

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

64.8

Melting Point:

182-183.3 °C

Boiling Point:

434.4ºC at 760mmHg

Flash Point:

216.5ºC

Water Solubility:

>49.6 [ug/mL]

See More Proparacaine hydrochloride Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Dermal

Skin sensitization, Category 1

Eye irritation, Category 2

Acute toxicity - Category 4, Inhalation

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H312 Harmful in contact with skin H317 May cause an allergic skin reaction H319 Causes serious eye irritation H332 Harmful if inhaled
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P271 Use only outdoors or in a well-ventilated area.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P317 Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P333+P317 If skin irritation or rash occurs: Get medical help. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Proparacaine hydrochloride Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid

Location:
Room 707, Block A, Zhongxing Times Digital Trade Port, No. 79 Xudong Street, Hongshan District, Wuhan City

Payment Terms:
TT against copy of documents,L/C

Average lead Time:
10 days

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2020

Company Certificates
- Verified supplier certificate
- SGS
Dingwang Technology (Wuhan) Co., Ltd located in the predominant WuHan City where is a traffic hinge of China,specilize in producing and developing pharmaceutical & its intermediates, Peptide, Nutritional supplements,food additive, Plant extracts,and in distributing the products of our own company and affiliated enterprises.
We have set up R&D center, quality inspection center and manufacturing site in Wuhan, Jiangsu and others places.
Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. Meanwhile, we possess of complete Q.A. and Q.C. system, supply chemical products with good quality and custom-tailored products according to our clients' requirement.
We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc.
With our constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
Brazil	Proxymetacaine Hydrochloride	1 KG	Oct 18, 2023
Brazil	Proparacaine Hydrochloride	1 KG	Oct 18, 2023
Pakistan	PROPARACAINE HYDROCHLORIDE	10 KG	Jul 29, 2026

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