Best Price Hair Loss Treatment 99% Setipiprant CAS 866460-33-5 Act-129968 Powder
GMP ISO
866460-33-5
Pharmaceutical Grade
99%
XAZB
Foil Bag
2022-12-31
Herb Extracts,Cosmetic raw materails,API
-
Product Description
-
Seller Information
-
Description
Setipiprant (INN) is a drug originally developed by Actelion which acts as a selective, orally available antagonist of the prostaglandin D2 receptor 2 (DP2). It was initially researched as a treatment for allergies and inflammatory disorders, particularly asthma, but despite being well tolerated in clinical trials and showing reasonable efficacy against allergen-induced airway responses in asthmatic patients, it failed to show sufficient advantages over existing drugs and was discontinued from further development in this application.Product Name:Setipiprant
Brand Name: ACT129968
CAS No.:866460-33-5
Molecular formula:C24H19FN2O3
Molecular weight: 402.42g/mol
Specification:Pharmaceutical Grade 99%
Appearance: Off-White Powder
Properties: Anti-Hair Loss,Baldness
Shelf Life :2 years
Storage:Room temperature, keep dry and away from light.
However, following the discovery in 2012 that the prostaglandin D2 receptor (DP/PGD2) is expressed at high levels in the scalp of men affected by male pattern baldness, the rights to setipiprant were acquired by Kythera with a view to potentially developing this drug as a novel treatment for baldness, with a previously unexploited mechanism of action. While it is too early to tell whether setipiprant will be an effective treatment for this condition, the favorable pharmacokinetics and relative lack of side effects seen in earlier clinical trials mean that fresh clinical trials for this new application can be conducted fairly quickly.
A phase 2A study is underway to evaluate the safety, tolerability, and efficacy of oral setipiprant relative to a placebo and the active comparator, finasteride, in 18 to 41 years old males with androgenetic alopecia.
1. Increase cellular proliferation of outer root sheeth cells.
2. Increase hair diameter and hair density.
3. Increase the percentage of hair in the anagen phase.
4. Exert no negative effect on body hormone levels.
5. Provide equivalent or better net growth than Finasteride.
CertificatesBasic Info-
Product Name:
Setipiprant
Other Name:5H-Pyrido[4,3-b]indole-5-acetic acid,8-fluoro-1,2,3,4-tetrahydro-2-(1-naphthalenylcarbonyl)-;8-Fluoro-1,2,3,4-tetrahydro-2-(1-naphthalenylcarbonyl)-5H-pyrido[4,3-b]indole-5-acetic acid;Setipiprant;ACT 129968;2-(2-(1-Naphthoyl)-8-fluoro-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)acetic acid;1263765-62-3
CAS No.:866460-33-5
Molecular Formula:C24H19FN2O3
InChIKeys:InChIKey=IHAXLPDVOWLUOS-UHFFFAOYSA-N
Molecular Weight:402.425
Exact Mass:402.42
UNII:BHF20LA2GM
DSSTox ID:DTXSID00235739
Categories:
Characteristics-
PSA:
62.5
XLogP3:3.39
Appearance:Light yellow to yellow solid
Density:1.4±0.1 g/cm3
Boiling Point:690.4±55.0 °C at 760 mmHg
Flash Point:371.4±31.5 °C
Refractive Index:1.682
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
Herb Extracts,Cosmetic raw materails,API
-
Location:
1403,Jinye B Block
-
Payment Terms:
TT against copy of documents
-
Average lead Time:
8
-
Total Annual Revenue:
$2.5 million-$5 million
-
Total Employees:
11-50
-
Year of Establishment:
2015
-
-
Country Product Purchase Quantity Date Posted Post an enquiry for this product