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Pharmaceutical Peptide Taltirelin,TA-0910 98% Powder 103300-74-9 Senwayer

Name: Pharmaceutical Peptide Taltirelin,TA-0910 98% Powder 103300-74-9 Senwayer
Brand: Senwayer
SKU: pr2209092447
Price: 100 USD
Availability: InStock

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CAS No.:

103300-74-9

Grade:

Top Product

Content:

98%

Port:

Wuhan

Brand:

Senwayer

Packaging:

vials,foil bag,drums

Sample Available:

Yes

Price valid (until):

2024-04-26

Contact Supplier

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Dingwang Technology (Wuhan) Co., Ltd.

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,L/C

Average Lead Time:

10 days

Qualification:

Main Products:

API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid

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Product Description
Seller Information
Inquiry History

Description

Product Detail

1. Product Basic Information

cas	103300-74-9
Name	Taltirelin
Synonyms	Taltirelin
MF	C17H23N7O5
Purity	99%
Application	Taltirelin(TA0910) is an orally active TRH analogue that binds to TRH receptors in the mouse brain.

2. Product Introduction

Taltirelin is the first approved oral thyrotropin-releasing hormone (TRH) in the world. In addition to endocrine effects, it can also exert certain central nervous system (CNS) effects, including improving motor activity, antagonizing Reserpine-induced hypothermia and antagonism of sleep.

Spinocerebellar ataxias (SCAs), formerly known as autosomal dominant ataxias, are a group of chronic degenerative diseases of the central nervous system with ataxia and dysmetria as the main clinical manifestations. Before September 2000, thyrotropin-releasing hormone (TRH) injection was the only drug used to treat this type of disease.

Tatirelin is a structurally modified drug of TRH. Pharmacological studies have shown that this product has strong and long-lasting multiple effects on the CNS through brain TRH receptors. The excitatory effect of this product on the CNS is 10 to 100 times stronger than that of TRH, and the duration of action is about 8 times longer than that of TRH. The affinity of this product to TRH receptor is about 1/11 of that of TRH, so the endocrine effect of this product is weaker than that of TRH, but this product is more stable than TRH in vivo.

In addition, the effect of this product on the release of thyrotropin (TSH) is 1/6-1/11 of that of TRH. The release of TSH is regulated by a strong negative feedback system including thyroid hormone and has a strong effect on the central nervous system. But at the same time, its hormone-like effect is small, so there are fewer side effects. Adverse reactions were mainly digestive system reactions, including vomiting, nausea and stomach upset. All adverse reactions were mild to moderate and disappeared during treatment and/or after drug withdrawal.

FAQ

Q1:Can i get free sample ?
A: Yes, most product we can send you small free sample, you just need to pay the shipping cost .

Q2:Which payment method you accept?
A: We accept bank transfer,western union, money gram,bitcoin, USDT,Credit card etc. and more bigger order we accept L/C at sight

Q3: Can i get tracking number after shipment ? and how long does the shipping take?
A: After shipment we will offer you tracking and tell you the website to track the package, usually the shipping time is 3-7days,but for some customers have no ability to declare customs, we use special line route to ship the package, it will take 10-12days to arrive,make sure 100% delivery

Q4: How can you guarantee the quality ?
A: All products we can supply you test report &you can also send our product to the third party to do test, if it is fake,we will full refund you.

Our Advantage

1. Rich experience.
Our company is a professional production leading factory in China in pharmaceutical area of many years, our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other country, and we have got very good feedback from our customers, we had Established long friendly relations of cooperation.

2. Great quality, purity and favourable.
Good quality is one of our secret success, welcome order the samples, MOQ just 1 grams.

3. Safe and fast delivery.
We have stock, so we can delivery quickly at the very day when receive the payment.

We have special way could ship 0.01kg to 3.5kg products a time. We offer melting powder into liquid service. And ship the liquid in special bottles.

4. Good after-sales service.

Tell me the package update, and will try best solve when customer encountered various problems.

ECHEMI Editorial Reference

Taltirelin was marketed in Japan for the treatment of neurodegenerative diseases, in particular the improvement of ataxia due to spino-cerebellar degeneration (SCD); it is the first orally-active drug in this indication. This synthetic thyrotropin-releasing hormone (TRH) analog is prepared by condensation of (S)-1-methyl-4,5-dihydroorotic acid with L-histidyl-Lprolinamide. It was shown that the S-configuration for all 3 chiral centers is crucial for CNS activity. Taltirelin is a potent agon
Taltirelin is an oligopeptide comprising of (4S)-1-methyl-2,6-dioxohexahydropyrimidine-4-carboxylic acid, L-histidine and L-prolinamide joined in sequence by peptide linkages. It is a thyrotropin-releasing hormone (TRH) analog. Its tetrahydrate form is approved in Japan for the treatment of spinal muscular atrophy. It has a role as a nootropic agent, a neuroprotective agent and an analgesic.

Research & Reference Note

Pharmaceutical Peptide Taltirelin,TA-0910 98% Powder 103300-74-9 Senwayer is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

Authoritative sources

Disclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

Reviewed by ECHEMI Scientific Review - Platform editorial review for research chemicals

Certificates

Basic Info

Product Name:

Taltirelin

Other Name:

L-Prolinamide,(4S)-hexahydro-1-methyl-2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl-;L-Prolinamide,N-[(hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl)carbonyl]-L-histidyl-,(S)-;(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl-L-prolinamide;TA 0910;Taltirelin;Ceredist

CAS No.:

103300-74-9

Molecular Formula:

C17H23N7O5

InChIKeys:

InChIKey=LQZAIAZUDWIVPM-SRVKXCTJSA-N

Molecular Weight:

405.41

Exact Mass:

405.41

UNII:

DOZ62MV6A5

DSSTox ID:

DTXSID0043763

Categories:

Polypeptide

Characteristics

PSA:

171

XLogP3:

-4.09

Density:

1.447±0.06 g/cm3(Predicted)

Melting Point:

72-75 °C

Refractive Index:

1.612

Storage Conditions:

Store at +4°C

Specific rotation:

25D -13.6° (c = 1 in water)

See More Taltirelin Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Taltirelin Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid

Location:
Room 707, Block A, Zhongxing Times Digital Trade Port, No. 79 Xudong Street, Hongshan District, Wuhan City

Payment Terms:
TT against copy of documents,L/C

Average lead Time:
10 days

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2020

Company Certificates
- Verified supplier certificate
- SGS
Dingwang Technology (Wuhan) Co., Ltd located in the predominant WuHan City where is a traffic hinge of China,specilize in producing and developing pharmaceutical & its intermediates, Peptide, Nutritional supplements,food additive, Plant extracts,and in distributing the products of our own company and affiliated enterprises.
We have set up R&D center, quality inspection center and manufacturing site in Wuhan, Jiangsu and others places.
Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. Meanwhile, we possess of complete Q.A. and Q.C. system, supply chemical products with good quality and custom-tailored products according to our clients' requirement.
We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc.
With our constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
United Kingdom	Taltirelin	1 G	Dec 29, 2023

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Pharmaceutical Peptide Taltirelin,TA-0910 98% Powder 103300-74-9 Senwayer

Product Description

Seller Information