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Tofacitinib

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Unit Price: Get Latest Price
CAS No.:

477600-75-2

Grade:

Pharmaceutical grade

Content:

0.99%

Packaging:

1KG;25KG;private logo

Price valid (until):

2023-09-01

Company Type:
Manufactory
Location:
China
Qualification:
Main Products:

Herb Extracts,Cosmetic raw materails,API

  • Product Description

  • Seller Information

  • Inquiry History

  • Description


      Tofacitinib


    Instruction:Tofacitinib (tofacitinibcitrate) chemical system name is 3-{(3R,4R) -4-methyl-3 -[methyl -(7H-pyrrolidine [2, 3-D] pyrimidine-4-yl) -piperidine-1-yl] -3-oxy-propanitrile citrate, for the United States Pfizer Company ( A Janus kinase inhibitor developed by Pfizer was approved by the U.S. Food and Drug Administration (FDA) on November 6, 2012 for the treatment of adults with moderately to severely active rheumatoid arthritis (RA) who do not respond adequately to or are intolerant to methotrexate therapy.

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    Certificates

    Basic Info
    Product Name:

    Tofacitinib

    Other Name:

    1-Piperidinepropanenitrile,4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-,(3R,4R)-;3-Piperidinamine,1-(cyanoacetyl)-4-methyl-N-methyl-N-1H-pyrrolo[2,3-d]pyrimidin-4-yl-,(3R,4R)-;(3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile;CP 690550;Tofacitinib;2097815-04-6

    CAS No.:

    477600-75-2

    Molecular Formula:

    C16H20N6O

    InChIKeys:

    InChIKey=UJLAWZDWDVHWOW-YPMHNXCESA-N

    Molecular Weight:

    312.3696

    Exact Mass:

    312.37

    EC Number:

    1806241-263-5

    UNII:

    87LA6FU830

    DSSTox ID:

    DTXSID90197271

    NCI Thesaurus Code:

    C95800

    Color/Form:

    Yellow foam

    ATC Code:

    L04AA29|L - Antineoplastic and immunomodulating agents

    HScode:

    29335990

    Categories:

    Inhibitors

    Characteristics
    PSA:

    88.9

    XLogP3:

    1.5

    Density:

    1.3±0.1 g/cm3

    Melting Point:

    White crystalline solid. MP: 199-206 °C /Tofacitinib monocitrate/

    Boiling Point:

    585.845ºC at 760 mmHg

    Flash Point:

    308.1±30.1 °C

    Refractive Index:

    1.646

    Water Solubility:

    In water, 155.1 mg/L at 25 deg C (est)

    Storage Conditions:

    Keep container tightly closed in a dry and well-ventilated place. /Tofacitinib citrate/

    Vapor Pressure:

    1.32X10-10 mm Hg at 25 deg C (est)

    Specific rotation:

    Specific optical rotation: +10.4 deg at 25 °C/D (c = 0.64 in methanol)

    Henrys Law Constant:

    Henry's Law constant = 3.17X10-21 atm-cu m/mol at 25 °C (est)

    Dissociation Constants:

    pKa1 = 8.46 (cyano); pKa2 = 13.56 (secondary amine)

    Experimental Properties:

    Hydroxyl radical reaction rate constant = 2.57X10-10 cu cm/molec-sec at 25 °C (est)

    Hazard Identification

    Classification of the substance or mixture

    Not classified.

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H301 Toxic if swallowed

    H311 Toxic in contact with skin

    H315 Causes skin irritation

    H319 Causes serious eye irritation

    H331 Toxic if inhaled

    H335 May cause respiratory irritation

    Precautionary statement(s)
    Prevention

    none

    Response

    none

    Storage

    none

    Disposal

    none

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Manufactory

    Main Products:

    Herb Extracts,Cosmetic raw materails,API

    Location:

    1403,Jinye B Block

    Payment Terms:

    TT against copy of documents

    Average lead Time:

    8

    Total Annual Revenue:

    $2.5 million-$5 million

    Total Employees:

    11-50

    Year of Establishment:

    2015

    Xian ZB Biotech Co.,Ltd is a leading Manufactory supplier of Arbutin, Nicotinamide, Flucytosine based in Xi'an, Shaanxi, China. With a commitment to quality and customer satisfaction, Xian ZB Biotech Co.,Ltd has become a trusted name in the industry. Our product line includes a range of high-quality Arbutin, Nicotinamide, Flucytosine, which are available at competitive prices. Xian ZB Biotech Co.,Ltd has established itself as a reliable supplier of chemical products on the echemi.com.

  • Inquiry History
    2 Inquiries
    Country Product Purchase Quantity Date Posted
    United States

    tofacitinib Factory Price 99% pure CAS 477600-75-2 tofacitinib powder

    100 G Aug 6, 2023
    Canada

    Tofacitinib

    10 G Nov 28, 2025
    Post an enquiry for this product
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