Native Clostridium histolyticum Collagenase
5 Inquiries
9001-12-1
Yes
2026-11-25
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Details
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Seller Information
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Inquiry History
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Description
ProductName Native Clostridium histolyticum Collagenase Cat No DIGS-253 Description Collagenases are endopeptidases that digest native collagen in the triple helix region. Collagens are the major fibrous component of animal extracellular connective tissue. Bacterial collagenases differ from vertebrate collagenases in that they exhibit broader substrate specificity (Peterkofsky 1982, Birkedal-Hansen 1987). Unlike animal collagenases that split collagen in its native triple-helical conformation (Woolley et al. 1975, Gross et al. 1974), bacterial collagenase is unique because it can degrade both water-insoluble native collagens and water-soluble denatured ones. It can attack almost all collagen types, and is able to make multiple cleavages within triple helical regions (Mookhtiar and Van Wart 1992). Abbr Collagenase (Clostridium histolyticum) Source Clostridium histolyticum Applications Isolation of adipocytes, hepatocytes, and cells from lung, epithelium and adrenal tissue Isolation of cardiomyocytes and cells from bone, cartilage, muscle, thyroid, and endothelium Isolation of mammary and various other soft tissues Isolation of human and porcine pancreatic islet cells (Kin 2007) Treatment of tissues with crude collagenase, with its mixture of proteolytic activities, provides gentle, selective digestion of the intercellular matrix with little damage to cells or loss of viability AFA collagenase is suitable for applications needing to avoid introduction of animal derived pathogens into bioprocessing procedures Product Overview Collagenase from Clostridium histolyticum Form Lyophilized powder Enzyme Commission Number EC 3.4.24.3 Activity Type 1 > 125 units per mg; Type 2 > 125 units per mg; Type 3 > 100 units per mg; Type 4 > 160 units per mg; Type 5 > 450 units per mg CAS No 9001-12-1 Molecular Weight 68 to 130 kDa Composition Clostridium collagenases represent unusually large metalloproteases, a family of proteases that shares a zinc-containing motif at the center of the active site (Gonzales and Robert-Baudouy 1996). Unit Definition One Unit releases one micromole of L-leucine equivalents from collagen in 5 hours at 37°C, pH 7.5. Optimum pH 6.3-8.5 Activators Ca2+ Zn2+ Stability This product is stable for at least one year when stored at-20°C. There is no loss in FALGPA or protease activity in 30 days at 37°C, 50°C and-20°C Inhibitors EDTA, EGTA Cysteine, histidine DTT 2-mercaptoethanol o-phenanthroline Hg2+, Pb2+, Cd2+, Cu2+, Zn2+ Not inhibited by DFP or serum Synonyms EC 3.4.24.3; Collagenase; Clostridiopeptidase A; Clostridium histolyticum collagenase; collagenase A; collagenase I; Achromobacter iophagus collagenase; aspergillopeptidase C; nucleolysin; Collagenase, Type 1; Collagenase, Type 2; Collagenase, Type 3; Collagenase, Type 4; Collagenase, Type 5 category Enzymes and Coenzymes Drugs(c1513) cas_num 9001-12-1 ECHEMI Editorial ReferenceA rare proteinase that catalyzes the hydrolysis of collagen. Collagenase activity has been demonstrated in several venoms of crotalid and viperid snakes and it occurs in certain species of clostridium.Basic Info-
Product Name:
Collagenase
Other Name:Collagenase;Collagenase A;Collagen peptidase;Collagen protease;Nucleolysin;Soycollagestin;Metallocollagenase;Collagenase type I;Collagenase type 1;Collagenase I;Collagenase 1;Morikraz;Matrix metalloprotease MMP-ABT;Euphaulysin;Collagenolytic enzymes;Endoenzymes,collagenolytic;Enzymes,collagen-degrading;Collalitine;Collalatine;Collagenase type A;Preprocollagenase;39433-96-0;106043-70-3;308064-64-4
CAS No.:9001-12-1
InChIKeys:YRQNKMKHABXEJZ-UVQQGXFZSA-N
Molecular Weight:849.4494
Exact Mass:812.418091
EC Number:232-582-9
HScode:3507907000
Categories:
Characteristics-
PSA:
25.8
XLogP3:21.9
Appearance:light brown powder
Water Solubility:Soluble in aqueous buffers.
Storage Conditions:2-8°C
Hazard IdentificationClassification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
Respiratory sensitization, Category 1
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H315 Causes skin irritation
H319 Causes serious eye irritation
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P284 [In case of inadequate ventilation] wear respiratory protection.
P271 Use only outdoors or in a well-ventilated area.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P342+P316 If experiencing respiratory symptoms: Get emergency medical help immediately.
P319 Get medical help if you feel unwell.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Inquiry History5 Inquiries
Country Product Purchase Quantity Date Posted 
Brazil
Collagenase
10 G Oct 9, 2025
Brazil
Colagenase
10 G Oct 9, 2025
Brazil
Colagenase
10 G Oct 4, 2025 
Russia
colagenase
1 KG May 2, 2025 
India
Collagenase
50 Jan 9, 2024 Post an enquiry for this product
