ARQ 197(Tivantinib)
905854-02-6
99%
Yes
2026-11-16
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
Tivantinib (CAS No.: 905854-02-6) is supplied by Creative Enzymes, a Manufactory with 6 years on ECHEMI.
Key details: content 99%.
Sample is available.
Contact the supplier on this page to request a quotation or the latest price.
ECHEMI Editorial ReferenceTivantinib is a novel and highly selective c-Met tyrosine kinase inhibitor with Ki of 355 nM.
LSM-1131 is a member of indoles.|Tivantinib has been investigated in Solid Tumors.|Tivantinib is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity. c-Met inhibitor ARQ 197 binds to the c-Met protein and disrupts c-Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met protein, the product of the proto-oncogene c-Met, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.Basic Info-
Product Name:
Tivantinib
Other Name:2,5-Pyrrolidinedione,3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-,(3R,4R)-;(3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-2,5-pyrrolidinedione;(3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione;Tivantinib;ARQ 197;1000873-98-2;1228508-24-4
CAS No.:905854-02-6
Molecular Formula:C23H19N3O2
InChIKeys:InChIKey=UCEQXRCJXIVODC-PMACEKPBSA-N
Molecular Weight:369.422
Exact Mass:369.42
UNII:PJ4H73IL17
NCI Thesaurus Code:C62437
Categories:
Characteristics-
PSA:
66.9
XLogP3:2.9
Density:1.5±0.1 g/cm3
Boiling Point:715.95°C at 760 mmHg
Flash Point:386.8±32.9 °C
Refractive Index:1.797
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 1B
Specific target organ toxicity â repeated exposure, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H360 May damage fertility or the unborn child
H373 May cause damage to organs through prolonged or repeated exposure
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response P318 IF exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
