2-Methoxyestradiol
362-07-2
99%
2026-07-13
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName 2-Methoxyestradiol Cat No CEI-0257 Description 2-Methoxyestradiol (2ME2) is a naturally occurring metabolite of 17beta-estradiol with antiproliferative, antiangiogenic, and proapoptotic activity, and is considered to have potential clinical benefit in the treatment of cancer. Alias 2-ME2 CAS No 362-07-2 Molecular Weight 302.41 Purity >99% Storage 2 years at -20 centigrade Synonyms 2-ME2 Targets hypoxia-inducible factor-1 Molecular Formula C19H2603 Chemical Name (8R,9S,13S,14S,17S)-2-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol Solubility DMSO 61 mg/mL Water In vitro 2-Methoxyestradiol (2ME2) is a naturally occurring metabolite of 17beta-estradiol with antiproliferative, antiangiogenic, and proapoptotic activity, and is considered to have potential clinical benefit in the treatment of cancer. 2-Methoxyestradiol (2ME2) can inhibit HCT116 and MCF7 with GI50 of 0.8 nM and 0.9 nM. 2ME2 does not interact with the estrogen receptors. Its major target is believed to be the cellular microtubule skeleton. 2ME2 has been shown to inhibit the polymerization of tubulin in vitro, thus disrupting normal microtubule function. However, at therapeutic doses in vivo, the drug is likely to act by impairing microtubule dynamics. Given that rapid microtubule dynamics are essential for the correct assembly and function of the mitotic spindle, 2ME2 activates the spindle assembly checkpoint and causes metaphase arrest, and as a consequence, inhibition of cell proliferation and induction of cellular apoptosis. In vivo 2-ME2 is an antiproliferative and anticancer agent for in vivo studies against Barrett esophageal adenocarcinoma (BEAC) and inhibiting the growth of BEAC xenografts. category Inhibitors(c1514) cas_num 362-07-2 Basic Info-
Product Name:
2-Methoxyestradiol
Other Name:Estra-1,3,5(10)-triene-3,17-diol,2-methoxy-,(17β)-;Estra-1,3,5(10)-triene-3,17β-diol,2-methoxy-;Estradiol,2-methoxy-;(17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol;2-Methoxyestradiol;2-Methoxyestra-1,3,5(10)-triene-3,17β-diol;2-Hydroxyestradiol 2-methyl ether;NSC 659853;Panzem;2ME2;2-Methoxy-E2;916057-22-2
CAS No.:362-07-2
Molecular Formula:C19H26O3
InChIKeys:InChIKey=CQOQDQWUFQDJMK-SSTWWWIQSA-N
Molecular Weight:302.41
Exact Mass:302.41
UNII:6I2QW73SR5
DSSTox ID:DTXSID3040938
NCI Thesaurus Code:C965
Categories:
Characteristics-
PSA:
49.7
XLogP3:4
Appearance:light yellow crystalline
Density:1.2±0.1 g/cm3
Melting Point:184-186 °C @ Solvent: Benzene
Boiling Point:464.4°C at 760 mmHg
Flash Point:234.7±28.7 °C
Refractive Index:1.586
Water Solubility:DMSO: 10 mg/mL
Storage Conditions:−20°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 3, Dermal
Skin irritation, Category 2
Eye irritation, Category 2
Acute toxicity - Category 3, Inhalation
Specific target organ toxicity â single exposure, Category 3
Carcinogenicity, Category 1B
Reproductive toxicity, Category 1B
Specific target organ toxicity â repeated exposure, Category 1
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301+H311+H331 Toxic if swallowed, in contact with skin or if inhaled
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
H350 May cause cancer
H360 May damage fertility or the unborn child
H372 Causes damage to organs through prolonged or repeated exposure
H410 Very toxic to aquatic life with long lasting effects
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P203 Obtain, read and follow all safety instructions before use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
P318 IF exposed or concerned, get medical advice.
P391 Collect spillage.
Storage P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product