DMXAA(ASA404)
117570-53-3
99%
2026-08-14
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName DMXAA(ASA404) Cat No CEI-0261 Description DMXAA(ASA404) can inhibit DT-diaphorase with IC50 of 20 uM. Alias AS-1404, 5, 6-MeXAA, NSC-640488, Vadimezan CAS No 117570-53-3 Molecular Weight 282.29 Purity >99% Storage 2 years at -20 centigrade Synonyms AS-1404, 5,6-MeXAA, NSC-640488, Vadimezan Targets DT-diaphorase Molecular Formula C17H14O4 Chemical Name 2-(5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid Solubility DSMO 7 mg/mL Water In vitro DMXAA is a competitive inhibitor of the enzyme DT-diaphorase (NAD(P)H:Quinone oxidoreductase EC 1.6.99.2) with respect to NADH, with Ki values of 20 microM, respectively. DMXAA partially inhibits cytochrome b5 reductase activity. And DMXAA is an antitumor agent which can halt tumor blood flow and cause hemorrhagic necrosis in transplantable murine tumors. In contrast to lipopolysaccharide, which induces high levels of serum TNF, DMXAA induces greater TNF production in tumors than in the spleen, liver, or serum. In vivo A single dose of DMXAA induced a prolonged reduction in the growth of xenografted tumours in animal models.In contrast to most agents, which require multiple dosing for an effect, DMXAA caused almost complete inhibition of bFGF-induced neovascularization of Matrigel implanted in athymic mice after a single administration of drug. category Inhibitors(c1514) cas_num 117570-53-3 Basic Info-
Product Name:
5,6-Dimethylxanthenone-4-acetic acid
Other Name:9H-Xanthene-4-acetic acid,5,6-dimethyl-9-oxo-;5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid;5,6-Dimethylxanthenone-4-acetic acid;NSC 640488;DMXAA;AS 1404;5,6-Dimethyl-9-oxo-9H-xanthen-4-ylacetic acid;Vadimezan;ASA 404;2-(5,6-Dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid;D5817;2-(5,6-Dimethyl-9-oxoxanthen-4-yl)acetic acid
CAS No.:117570-53-3
Molecular Formula:C17H14O4
InChIKeys:InChIKey=XGOYIMQSIKSOBS-UHFFFAOYSA-N
Molecular Weight:282.29
Exact Mass:282.29
EC Number:700-141-4
UNII:0829J8133H
DSSTox ID:DTXSID2040949
NCI Thesaurus Code:C2504
HScode:2932999099
Categories:
Characteristics-
PSA:
63.6
XLogP3:3.2
Appearance:light brown solid
Density:1.321±0.06 g/cm3(Predicted)
Melting Point:259-261 °C
Boiling Point:520.9±50.0 °C(Predicted)
Flash Point:197.1±23.6 °C
Refractive Index:1.633
Water Solubility:DMSO: 17 mg/mL, soluble
Storage Conditions:2-8°C
Vapor Pressure:1.12E-11mmHg at 25°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
H400 Very toxic to aquatic life
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P391 Collect spillage.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
