AZ 3146
1124329-14-1
99%
2026-07-11
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName AZ 3146 Cat No CEI-0337 Description AZ 3146 CAS No 1124329-14-1 Molecular Weight 452.55 Purity >99% Storage 2 years at -20 centigrade Targets MSP1 Molecular Formula C24H32N6O3 Solubility No In vitro AZ3146 inhibits human Mps1Cat with an IC50 of 35 nM. AZ3146 also efficiently inhibited autophosphorylation of full-length Mps1 immunoprecipitated from human cells. AZ3146 is a reasonably potent and selective Mps1 inhibitor. AZ3146 overrides the spindle checkpoint. HeLa cells treated with nocodazole and 2 uM AZ3146 only delayed mitosis briefly and then rereplicated their genomes. During an otherwise unperturbed mitosis, AZ3146 reduced the time to complete mitosis from 90 min in controls to 32 min. During mitosis, Mps1 activity is required continuously to recruit Mad2 to kinetochore-bound Mad1, but AZ3146 can abolish Mad2 localization. And inhibition of Mps1 by AZ3146 can increase its abundance at kinetochores. category Inhibitors(c1514) cas_num 1124329-14-1 Basic Info-
Product Name:
9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
Other Name:9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one;AZ 3146;9-cyclopentyl-2-(2-Methoxy-4-(1-Methylpiperidin-4-yloxy)phenylaMino)-7-Methyl-7H-purin-8(9H)-one;9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one;9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-oneAZ3146;9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9
CAS No.:1124329-14-1
Molecular Formula:C24H32N6O3
InChIKeys:YUKWVHPTFRQHMF-UHFFFAOYSA-N
Molecular Weight:453
Exact Mass:452.253601
Categories:
Characteristics-
PSA:
83.1
XLogP3:3.2
Density:1.279
Boiling Point:621.0±65.0 °C(Predicted)
Flash Point:329.4±34.3 °C
Refractive Index:1.631
Storage Conditions:Store at +4°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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