Bromodomain Inhibitor,(+)-JQ1
1268524-70-4
99%
Yes
2026-11-17
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Bromodomain Inhibitor, (+)-JQ1 Cat No CEI-0409 Description Cell-permeable. A potent and highly specific inhibitor for the BET (bromodomain and extra-terminal) family of bromodomains. (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~ 50 and 90 nM, respectively. The binding is competitive with acetyl lysine. (+)-JQ1 can be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis. Appearance Crystalline solid Product Overview A potent and highly specific BET inhibitor CAS No 1268524-70-4 Molecular Weight 349.43 Purity >99% by HPLC Storage -20 centigrade Targets BRD4 Molecular Formula C23H25ClN4O2S Chemical Name t-Butyl-2-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate Solubility DMSO Shipping Conditions RT category Inhibitors(c1514) cas_num 1268524-70-4 ECHEMI Editorial Reference(+)-JQ-1 is a BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2)).Basic Info-
Product Name:
JQ 1(+)
Other Name:6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid,4-(4-chlorophenyl)-2,3,9-trimethyl-,1,1-dimethylethyl ester,(6S)-;1,1-Dimethylethyl (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetate;(+)-JQ 1;JQ 1;(S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;JQ1 (pharmaceutical);JQ 1(+);tert-Butyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;(S)-JQ1;JQ1 (BET inhibitor);BET domain inhibitor JQ1;Bromodomain and extra-terminal domain inhibitor JQ1
CAS No.:1268524-70-4
Molecular Formula:C23H25ClN4O2S
InChIKeys:InChIKey=DNVXATUJJDPFDM-KRWDZBQOSA-N
Molecular Weight:456.9882
Exact Mass:456.99
Categories:
Characteristics-
PSA:
97.6
XLogP3:4.9
Appearance:white to beige
Density:1.33
Boiling Point:610.4±65.0 °C(Predicted)
Flash Point:322.9±34.3 °C
Refractive Index:1.657
Water Solubility:DMSO: soluble20mg/mL, clear
Storage Conditions:2-8°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
