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JQ 1(+)

JQ 1(+) structure

CAS No:
1268524-70-4
Formula:
C23H25ClN4O2S
Chemical Name:
JQ 1(+)
Synonyms:
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid,4-(4-chlorophenyl)-2,3,9-trimethyl-,1,1-dimethylethyl ester,(6S)-;1,1-Dimethylethyl (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetate;(+)-JQ 1;JQ 1;(S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;JQ1 (pharmaceutical);JQ 1(+);tert-Butyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;(S)-JQ1;JQ1 (BET inhibitor);BET domain inhibitor JQ1;Bromodomain and extra-terminal domain inhibitor JQ1
Categories:
Biochemical Engineering > Inhibitors

Description

(+)-JQ-1 is a BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2)).

Molecular Weight：

456.9882

Exact Mass：

456.99

PSA：

97.6

XLogP3：

4.9

Appearance：

white to beige

Density：

1.33

Boiling Point：

610.4±65.0 °C(Predicted)

Flash Point：

322.9±34.3 °C

Refractive Index：

1.657

Water Solubility：

DMSO: soluble20mg/mL, clear

Storage Conditions：

2-8°C

Transport codes：

NONH for all modes of transport

BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation.

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