MLN 2480
1 Inquiries
1096708-71-2
0.98%
2026-10-05
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Product Description
-
Seller Information
-
Inquiry History
-
Description
ProductName MLN 2480 Cat No CEI-1434 Description MLN 2480 is an oral, selective inhibitor of Raf kinases. Product Overview MLN2480 is an potent pan-RAF kinase inhibitor. CAS No 1096708-71-2 Molecular Weight 506.29 Purity 0.98 Storage Store at -20°C Synonyms BIIB024, BIIB 024, BIIB-024, MLN2480, MLN 2480, MLN-2480 Targets Pan-Raf kinase Molecular Formula C17H12Cl2F3N7O2S Chemical Name 2-[(1R)-1-[(6-amino-5-chloropyrimidine-4-carbonyl)amino]ethyl]-N-[5-chloro-4-(trifluoromethyl)pyridin-2-yl]-1,3-thiazole-5-carboxamide Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request In vitro MLN2480 inhibits MAPK pathway signaling in BRAF mutant and some RAS mutant preclinical cancer models at concentrations that are tolerated in vivo. In vitro analysis of this drug combination of MLN2480 and TAK-733 in cell proliferation assays demonstrates synergistic activity. In vivo MLN2480 is most potent in BRAF mutant melanoma models but also has single agent activity in some RAS mutant models. The MLN2480 and TAK-733 combination inhibits the growth of a broader range of RAS mutant tumor models than MLN2480 single agent, including primary human tumor xenograft models of melanoma and CRC. category Specialty Chemicals(c26) cas_num 1096708-71-2 ECHEMI Editorial ReferenceMLN 2480 is an orally active and selective inhibitor of pan-Raf kinase.
TAK-580 is a 1,3-thiazolecarboxamide that is 2-[(1R)-1-aminoethyl]-1,3-thiazole-5-carboxylic acid in which the carboxy group undergoes formal condensation with the amino group of 5-chloro-4-(trifluoromethyl)pyridin-2-amine and in which the amino group undergoes formal condensation with the carboxy group of 6-amino-5-chloropyrimidine-4-carboxylic acid. It is a pan-RAF kinase inhibitor which is currently in clinical development for the treatment of radiographically recurrent or progressive low-grade glioma in children and young adults. It has a role as an antineoplastic agent, an apoptosis inducer and a B-Raf inhibitor. It is a chloropyridine, an organofluorine compound, a secondary carboxamide, an aminopyrimidine, a pyrimidinecarboxamide and a 1,3-thiazolecarboxamide.|TAK-580 is under investigation in clinical trial NCT02723006 (Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of Investigational Treatments in Combination With Standard of Care Immune Checkpoint Inhibitors in Participants With Advanced Melanoma).Basic Info-
Product Name:
6-Amino-5-chloro-N-[(1R)-1-[5-[[[5-chloro-4-(trifluoromethyl)-2-pyridinyl]amino]carbonyl]-2-thiazolyl]ethyl]-4-pyrimidinecarboxamide
Other Name:6-Amino-5-chloro-N-[(1R)-1-[5-[[[5-chloro-4-(trifluoromethyl)-2-pyridinyl]amino]carbonyl]-2-thiazolyl]ethyl]-4-pyrimidinecarboxamide;BIIB-024;MLN 2480;MLN2480 (BIIB-024);(R)-2-(1-(6-Amino-5-chloropyrimidine-4-carboxamido)ethyl)-N-(5-chloro-4-(trifluoromethyl)pyrid
CAS No.:1096708-71-2
Molecular Formula:C17H12Cl2F3N7O2S
InChIKeys:VWMJHAFYPMOMGF-ZCFIWIBFSA-N
Molecular Weight:506.2890896
Exact Mass:505.01000
UNII:ZN90E4027M
DSSTox ID:DTXSID70149011
Categories:
Characteristics-
PSA:
164
XLogP3:3
Density:1.64
Boiling Point:585.3±50.0 °C(Predicted)
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Location:
Shirley, New York 11967, USA
-
Payment Terms:
TT against copy of documents,D/P
-
Average lead Time:
15
-
Total Annual Revenue:
$1 million-$2.5 million
-
Year of Establishment:
2004
-
-
Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
India
Tovorafenib
1 KG Aug 7, 2025 Post an enquiry for this product
- Hot Searches
- 6-aminohexanoic acid
- naphthapreis
- trimethylaluminum sds
- cheapest retatrutide
- retatrutide glp-3 for sale
- anhydrous ammonia suppliers near me
- propene price
- price of base oil
- heat+shrinkable+fluoropolymer+tubing
- dapagliflozin propanediol 10 mg tablet
- retatrutide buy online
- msds of acetaminophen