Semaglutide Side Chain 99%/ tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu
2 Inquiries
1118767-16-0
Pharmaceutical Grade
99%
Any port in China
Double layer polyethylene bag , single-layer aluminum-plastic film bag
Yes
2023-08-15
Functional Food Ingredients (Chondroitin sulfate),3,5-di-tert-butylsalicylic acid,TBPB,Cosmetic Ingredients(PDRN&PN, EGT,HA, Ectoine),API & Intermediates(Semaglutide&related products),Agrochemicals
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferencetBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu is the 18-carbon fatty acid side chain of somatostatin, which contributes to an increased affinity for albumin (approximately 5-6 fold). Somalutide is a glucagon-like peptide-1 (GLP-1) analogue with hypoglycaemic properties.
TBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu is also known as Semaglutide Side Chain. An 18-carbon fatty acid side chain of semaglutide. The affinity of the semaglutide side chain for albumin was enhanced 5-6 times. Semaglutide is a glucagon-like peptide-1 (GLP-1) analog with significant hypoglycemic efficacy.
tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu, as the side chain of semaglutide, can be used in the solid-phase and semi-synthetic recombinant fermentation process of semaglutide.Basic Info-
Product Name:
tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu
Other Name:(S)-22-(Tert-butoxycarbonyl)-10,19,24-trioxo-3,6,12,15-tetraoxa-9,18,23-triazahentetracontane-1,41-dioic acid;Octadecane(OtBu)-Glu(ɑ-OtBu)-AEEA-AEEA-OH;Side chain;tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu;Semaglutide side chain;Fmoc-L-Lys[OctotBu)-Glu-(otBu)-AEEA-AEEA]-OHu;(S)-22-(tert-butoxycarbonyl)-43,43-dimethyl-10,19,24,41-tetraoxo-3,6,12,15,42-pentaoxa-9,18,23-triazatetratetracontanoic acid;Egf(a) analogue-13C4
CAS No.:1118767-16-0
Molecular Formula:C43H79N3O13
InChIKeys:YZUXNRZPWYRMGH-DHUJRADRSA-N
Molecular Weight:846.1
Color/Form:White to off-white
Categories:
Characteristics-
Density:
1.079±0.06 g/cm3(Predicted)
Boiling Point:940.6±65.0 °C(Predicted)
PKA:3.39±0.10(Predicted)
Critical Temperature & Pressure:Keep in dark place, Sealed in dry, Store in freezer, under -20°C
Research-
Class:
GLP-1R agonist
Status:FDA-approved (Ozempic / Wegovy / Rybelsus)
Mechanism:Long-acting, selective glucagon-like peptide-1 (GLP-1) receptor agonist with 94% sequence homology to human GLP-1. Engineered for extended half-life (~1 week) via albumin binding (fatty acid acylation at Lys26) and resistance to DPP-4 degradation (Aib substitution at position 8). Promotes insulin secretion, inhibits glucagon release, delays gastric emptying, and reduces appetite via central nervous system GLP-1R activation.
Activity note:Potent, selective GLP-1R agonist. Reported binding affinity Ki = 0.38 ± 0.06 nM. Semaglutide is a human GLP-1 analog with structural modifications for albumin binding (C18 fatty diacid at Lys26) and enzymatic stability (Aib8 substitution).
Source:Lau J, et al. J Med Chem. 2015;58(18):7370-7380. Wilding JPH, et al. N Engl J Med. 2021;384(11):989-1002.DOI
Clinical Development:FDA:Ozempic, Wegovy, Rybelsus (approved 2017-12-05)
References-
ChEMBL:DrugBank:KEGG DRUG:PubChem:Literature:
NEJM: Wilding et al. (2021) — STEP-1; NEJM: Marso et al. (2016) — SUSTAIN-6; J Med Chem: Lau et al. (2015) — Discovery of Semaglutide; FDA: Ozempic (NDA 209637)
Disclaimer:Semaglutide is approved as a prescription medicine (Ozempic, Wegovy, Rybelsus) in certain jurisdictions. This listing is for industrial and laboratory research use only. Research-chemical listings on B2B marketplaces are not interchangeable with approved medicines. Confirm CAS, specification, and regulatory pathway with the seller. It is not medical advice, a clinical recommendation, or an approved therapy description.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Functional Food Ingredients (Chondroitin sulfate),3,5-di-tert-butylsalicylic acid,TBPB,Cosmetic Ingredients(PDRN&PN, EGT,HA, Ectoine),API & Intermediates(Semaglutide&related products),Agrochemicals
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Location:
Rm333-3F,1st building,No.59 Tianyuan West Road,Jiangning,NANJING CHINA
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Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
14 days
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2017
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Inquiry History2 Inquiries
Country Product Purchase Quantity Date Posted 
India
tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu
10 KG May 7, 2025
India
(tBu-OOC-C16-CO-Glu(AEEA-AEEA)-OtBu)-OSU
1 KG Mar 2, 2024 Post an enquiry for this product
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