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China Most Professional Manufacturer Supply High Qulity BETA-Arbutin(Arbutin) CAS 497-76-7

Name: China Most Professional Manufacturer Supply High Qulity BETA-Arbutin(Arbutin) CAS 497-76-7
Brand: Leader
SKU: pr2311261202
Price: 1 USD
Availability: InStock

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CAS No.:

497-76-7

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

Leader

Packaging:

25KG/Drum

Price valid (until):

2023-12-26

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LEADER BIOCHEMICAL GROUP

Company Type:

Manufactory

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

5 days

Qualification:

Main Products:

Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients

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Product Description
Seller Information
Inquiry History

Description

About Product Technical Details

Arbutin Chemical Properties

Melting point	195-198 °C
alpha	-64 º (c=3)
Boiling point	375.31°C (rough estimate)
density	1.3582 (rough estimate)
refractive index	-65.5 ° (C=4, H2O)
storage temp.	Inert atmosphere,Room Temperature
solubility	H₂O: 50 mg/mL hot, clear
form	neat
pka	10.10±0.15(Predicted)
color	White
optical activity	[α]/D -64.0±2.0°, c = 3 in H2O
Water Solubility	10-15 g/100 mL at 20 ºC
Sensitive	Hygroscopic
Merck	14,773
BRN	89673
Stability:	Stable. Hygroscopic - store under dry nitrogen.
InChIKey	BJRNKVDFDLYUGJ-RMPHRYRLSA-N
LogP	-1.350
CAS DataBase Reference	497-76-7(CAS DataBase Reference)
EPA Substance Registry System	.beta.-D-Glucopyranoside, 4-hydroxyphenyl (497-76-7)

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	22-24/25-36-26
WGK Germany	3
RTECS	CE8863000
F	3-10-23
HS Code	29389090

Product Pictures

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Shop China Largest factory Manufacturer Supply High Qulity 4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy CAS 2226-96-2-Detailed Image 4

About Our Group

Since 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture high quality raw materials and refined ingredients which is widely used at different industries areas like Pharm & chemicals industry, functional active ingredients industry, nutritional Ingredients industry, health care products industry, cosmetics industry, pharmaceutical and refined food, feed, oil industry, natural plant ingredients industries, agriculture industry etcs to provide top quality of GMP standards products.

All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, agriculture raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China.

Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research. Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates.

With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products. Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people.

We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.

We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

Our Factories Production Lines

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Our Factories R&D ability

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Our Factories warehouse 52000㎡

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Sales Team

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ECHEMI Editorial Reference

Arbutin(β-Arbutin) is a glycoside; a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos; inhibits tyrosinase and thus prevents the formation of melanin.IC50 value:Target: tyrosinase
Solid
Hydroquinone O-beta-D-glucopyranoside is a monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage. It has a role as a plant metabolite and an Escherichia coli metabolite. It is a beta-D-glucoside and a monosaccharide derivative. It derives from a hydroquinone.|Extracted from the dried leaves of bearberry plant in the genus Arctostaphylos and other plants commonly in the Ericaceae family, arbutin is a beta-D-glucopyranoside of [DB09526]. It is found in foods, over-the-counter drugs, and herbal dietary supplements. Most commonly, it is an active ingredient in skincare and cosmetic products as a skin-lightening agent for the prevention of melanin formation in various skin conditions that involve cutaneous hyperpigmentation or hyperactive melanocyte function. It has also been used as an anti-infective for the urinary system as well as a diuretic. Arbutin is available in both natural and synthetic forms; it can be synthesized from acetobromglucose and [DB09526]. Arbutin is a competitive inhibitor of tyrosinase (E.C.1.14.18.1) in melanocytes, and the inhibition of melanin synthesis at non-toxic concentrations was observed in vitro. Arbutin was shown to be less cytotoxic to melanocytes in culture compared to [DB09526].

Certificates

Basic Info

Product Name:

Arbutin

Other Name:

β-D-Glucopyranoside,4-hydroxyphenyl;Arbutin;Glucopyranoside,p-hydroxyphenyl,β-D-;4-Hydroxyphenyl β-D-glucopyranoside;Ursin;p-Hydroxyphenyl β-D-glucoside;p-Hydroxyphenyl β-D-glucopyranoside;Hydroquinone β-D-glucopyranoside;Arbutine;Uvasol;β-Arbutin;Hydroquinone glucose;Arbutoside;NSC 4036;Arbutyne;p-Arbutin;30373-96-7;39464-18-1;1779499-53-4

CAS No.:

497-76-7

Molecular Formula:

C12H16O7

InChIKeys:

InChIKey=BJRNKVDFDLYUGJ-RMPHRYRLSA-N

Molecular Weight:

272.25100

Exact Mass:

272.25

EC Number:

207-850-3

UNII:

C5INA23HXF

DSSTox ID:

DTXSID7040152

Color/Form:

Colorless elongated prisms from moist ethyl acetate|White powder (pure synthetic)|Needles (water + 1)

HScode:

29389090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

119.61000

XLogP3:

-0.7

Appearance:

white powder

Density:

1.556g/cm3

Melting Point:

199.5 °C

Boiling Point:

561.6ºC at 760 mmHg

Flash Point:

293.4ºC

Refractive Index:

1.65

Water Solubility:

H2O: 10-15 g/100 mL at 20 ºC

Vapor Pressure:

1.9E-13mmHg at 25°C

Specific rotation:

Specific optical rotation: -60.3 deg at 20 °C/D (in water)

Henrys Law Constant:

Henry's Law constant = 1.20X10-19 atm-cu m/mol at 25 °C (est)

Collision Cross Section:

166.6 Å² [M+Na]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|159.52 Å² [M+Na-2H]- [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|164.4 Å² [M+Na]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Experimental Properties:

MP 199 °C after sintering at 163-164 °C ... Also reported as unstable form, mp 165 °C; stable form, mp 199.5-200 °C|Hydroxyl radical reaction rate constant = 9.10X10-11 cu cm/molec-sec at 25 °C (est)

See More Arbutin Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Arbutin Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients

Location:
National Aerospace Economic & Technical Development Zone,Chang'an,Xi'an,China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
5 days

Total Annual Revenue:
$10 million-$25 million

Total Employees:
Above 1000

Year of Establishment:
2014

Company Certificates
- Level A of Tax Credit Registration Assessment by Government
- Good Product Quality Management Certificate of Shanxi Province,China
- Company Trade Union Qualification Certificate
- Excellent Group Enterprise of Quality and credit in Shaanxi ProvinceChina
- AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China
- FDA
24 Hours Team Service
Email
info@leader-biogroup.com
Hot Line
+86-029-68895030
+86-029-68569961
+86-029-68569962
Fax
+86-029-68895030

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories Base with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world.
- Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.
  
  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.
  
  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.
  
  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.
- Process Capability : It has more than 100 sets of multi-functional reaction reactors, such as 100l~6300l enamel, stainless steel, Hastelloy, etc. It can realize Grignard, coupling, bromination, Wittig reaction and other conventional reactions. There are microchannel reactor workshops, which can realize continuous production, energy conservation and emission reduction. It can realize high pressure, high vacuum rectification, ultra-low temperature (-80 ℃ ~-100 ℃), ultra-high temperature (300 ℃ ~400 ℃) and other special reactions. It can realize the customization and processing of customers' products.
Factory Overview

   Factory Production Lines

Our Professional Lab

Factory Warehouse

Factory Logistics Departments
GROUP HONOR
Honor Name: Level A of Tax Credit Registration Assessment
Issued By:National Administration of Taxation & Shaanxi Tax Bureau
Authorised Date:2018-09-16
Description: National Administration of Taxation & Shaanxi Tax Bureau

Honor Name: AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China
Issued By:China Association of Shaanxi product Quality management Center
Authorised Date:2018-12-31
Description:AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China

Honor Name:Excellent Group Enterprise of Quality and credit in Shaanxi ProvinceChina
Issued By: China Association of Shaanxi product Quality management Center
Authorised Date:2018-12-31
Description: Excellent Group Enterprise of Quality and Integrity in Shaanxi Province,China

Honor Name: Products Patent Certificates

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	beta arbutin	2.00 KG	Nov 5, 2025
Brazil	Arbutin	1 20' Fcl	Nov 28, 2024
India	Beta arbutin	100.00 KG	Jul 4, 2024

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China Most Professional Manufacturer Supply High Qulity BETA-Arbutin(Arbutin) CAS 497-76-7

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

Factory Logistics Departments

GROUP HONOR

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Email	info@leader-biogroup.com
Hot Line	+86-029-68895030
	+86-029-68569961
	+86-029-68569962
Fax	+86-029-68895030