Factory Supply High Quality sodium metabisulfite 99% Solid CAS7681-57-4

Bioactivity of sodium pyrosulfite
Description Sodium metabisulfite can be used as excipients, such as antibacterial agents, preservatives, antioxidants, etc. Pharmaceutical excipients, or pharmaceutical excipients, refer to other chemical substances used in the pharmaceutical process in addition to pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs [1].
Related category
Field of Study >> Other
Signal Path >> Other >> Other
reference
[1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25; 87:88-99.

Physical and chemical properties of sodium pyrosulfite
Density 1.48
Melting point 150 °C
Molecular formula Na2O5S2
Molecular weight 190.11
Accurate mass 189.898254
PSA 124.92000
LogP 0.27220
Appearance properties White crystalline powder
Storage condition
1. It should be stored in a cool and dry warehouse. The package is sealed and should prevent air oxidation.

2. Pay attention to moisture. It should be protected from rain and hot sun during transportation. It is strictly prohibited to store and transport with acids, oxidants and toxic and harmful substances.

3. Fire can be put out with water and various fire extinguishers.

stability
1. Easily decomposed by moisture, easily oxidized into sodium sulfate when exposed to air. It's stimulating.

2. Contact with strong acid releases sulfur dioxide and generates corresponding salts. Decomposition when heated to 150℃. A white powder with a strong SO2 odor that loses SO2 in the air and absorbs O2 to convert to Na2SO4. Easily soluble in water, the aqueous solution is acidic, and when the solution is heated to more than 65 ° C, it is decomposed into Na2SO3 and SO2.

Water solubility 540 g/L (20 ºC)
Computational chemistry
1. Reference value for calculating hydrophobic parameters (XlogP) : None

2. Number of hydrogen bond donors :0

3. Number of hydrogen bond receptors :6

4. Number of rotatable chemical bonds :0

5. Number of tautomers: None

6. Topological molecular polar surface area 125

7. Number of heavy atoms :9

8. Surface charge :0

9. Complexity :136

10. Number of isotope atoms :0

11. Determine the number of protonic centers :0

12. Number of uncertain atomic stereocentes :0

13. Determine the number of chemical bond structure centers :0

14. Number of uncertain chemical bond stereocenter :0

15. Number of covalent bond units :3

more
1. Properties: white or slightly yellow crystalline powder, with sulfur dioxide odor

2. Density (g/mL 25ºC) : 1.48

3. Relative vapor density (g/mL, air =1) : 1.10

4. Melting point (ºC) : 150

5. Boiling point (ºC, atmospheric pressure) : not determined

6. Boiling point (ºC,5.2kPa) : not determined

7. Refractive index (n20/D) : not determined

8. Flash point (ºC,) : Undetermined

9. Specific rotation (º) : - Not determined

10. Spontaneous ignition point or ignition temperature (ºC) : not determined

11. Vapor pressure (kPa,25ºC) : not determined

12. Saturated vapor pressure (kPa,60ºC) : not determined

13. Heat of combustion (KJ/mol) : not determined

14. Critical temperature (ºC) : not determined

15. Critical pressure (KPa) : not determined

16. The value of oil-water (octanol/water) partition coefficient (25℃) : not determined

17. Upper explosion limit (%,V/V) : not determined

18. Lower explosive limit (%,V/V) : not determined

19. Solubility (mg/mL) : soluble in water (54g/100ml water at 20℃; 81.7g/100ml water at 100℃), the aqueous solution is acidic. Soluble in glycerol, slightly soluble in ethanol