Factory Supply High Quality Huperzine A 99% Solid CAS102518-79-6

(-) -huperzine A biological activity
Description Huperzine A is an active lycopodium alkaloid extracted from traditional Chinese herbs. It is a reversible acetylcholinesterase (ACE) inhibitor and is widely used in Alzheimer's disease in China.
Related category
Signaling Pathways >> Nerve Signaling Pathways >> Pain
Natural Products >> Alkaloids
Research Areas >> Neurological diseases
reference
[1]. Burshtein G, Friedman M, Greenberg S, Hoffman A. Transepithelial Transport of a Natural Cholinesterase Inhibitor, Huperzine A, along the Gastrointestinal Tract: the Role of Ionization on Absorption Mechanism. Planta Med. 2013 Jan 23.

[2]. Ruan Q, Liu F, Gao Z, et al. The anti-inflamm-aging and hepatoprotective effects of huperzine A in d-galactose-treated rats. Mech Ageing Dev. 2013 Jan 8. pii: S0047-6374(12)00182-0.

[3]. Zhang HY. New insights into huperzine A for the treatment of Alzheimer's disease. Acta Pharmacol Sin. 2012 Sep; 33 (9) : 1170-5.

[4]. Wang J, Zhang HY, Tang XC. Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion. J Neurosci Res. 2010 Mar; 88(4):807-15. doi: 10.1002/jnr.22237.

[5]. Park P, Schachter S, Yaksh T. Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats. Neurosci Lett. 2010 Feb 5; 470 (1) : 6-9. Doi: 10.1016 / j. eulet. 2009.12.033.

(-)- Physical and chemical properties of huperzine A
Density 1.6± 0.1g /cm3
Boiling point 479.5±25.0 °C at 760 mmHg
Melting point: 211-216oC
Molecular formula C15H18N2O
Molecular weight 242.32
Flash point 243.8±23.2 °C
PSA 58.88000
LogP minus 0.22
Appearance White to light white crystalline powder
Vapor pressure 0.0±1.2 mmHg at 25°C
Refractive index 1.741
Storage condition
Sealed in a cool and dry environment of -20 ºC

stability
It will not decompose when used and stored according to regulations.

Molecular structure
1, molar refractive index: 71.47

2. Molar volume (m3/mol) : 201.8

3. Isotropic specific volume (90.2K) : 535.2

4, surface tension (dyne/cm) : 49.4

5, polarizability (10-24cm 3) : 28.33

Computational chemistry
1. Reference value of hydrophobic parameter calculation (XlogP) : 0

2. Number of hydrogen bond donors: 2

3. Number of hydrogen bond receptors: 2

4. Number of rotatable chemical bonds: 0

5. Topological molecular polar surface area (TPSA) : 55.1

6. Number of heavy atoms: 18

7, surface charge: 0

8. Complexity: 551

9. Number of isotope atoms: 0

10. Determine the number of atomic stereocenter: 0

11. Number of uncertain atomic stereocentes: 2

12. Determine the number of chemical bond structure centers: 1

13. Number of uncertain chemical bond structure centers: 0

14. Number of covalent bond units: 1

more
1. Traits: No use

2. Density (g/mL,25/4℃) : not available

3. Relative vapor density (g/mL, air =1) : not available

4. Melting point (ºC) : 211-216

5. Boiling point (ºC, atmospheric pressure) : Not available

6. Boiling point (ºC,5.2kPa) : Not available

7. Refractive index: No use

8. Flash point (ºC) : Unavailable

9. Specific rotation (º) : Not available

10. Spontaneous ignition point or ignition temperature (ºC) : Not available

11. Vapor pressure (kPa,25ºC) : Not available

12. Saturated vapor pressure (kPa,60ºC) : Not available

13. Heat of combustion (KJ/mol) : No use

14. Critical temperature (ºC) : Not available

15. Critical pressure (KPa) : Not available

16. Pairs of oil-water (octanol/water) distribution coefficients: not available

17. Upper explosion limit (%,V/V) : Not available

18. Lower explosive limit (%,V/V) : Not available

19. Solubility: No use