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Home > Active Pharmaceutical Ingredients > Hormones and the Endocrine System > Tofacitinib for Sale > Factory supply Tofacitinib CAS 477600-75-2 with good price
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Factory supply Tofacitinib CAS 477600-75-2 with good price

2 Inquiries

Unit Price: Get Latest Price
CAS No.:

477600-75-2

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

COMINGS

Packaging:

1g,5g,10g,100g,1000g

Price valid (until):

2025-05-14

Company Type:
Trader
Location:
China
Qualification:
Main Products:

semaglutide,tirzepatide,Liraglutide,Retatrutide,5-amino-1MQ,SLU-PP-332

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    Tofacitinib CAS 477600-75-2 Details


    CAS

    477600-75-2

    Name

    Tofacitinib (CP-690550)

    Purity

    99%

    Synonyms

    Tofacitinib

    Molecular formula:

    C16H20N6O


    Molecular Weight

    312.370

    Shelf  Life

     2 Years

    Package

    25kg,10kg,5kg,1kg


       

    What is Tofacitinib CAS 477600-75-2 ?


    1. Empagliflozin is a selective sodium-glucose co-transporter-2 (SGLT-2) inhibitor with significant pharmacological characteristics and potential clinical applications. Its mechanism of action primarily involves the inhibition of SGLT-2, a protein responsible for the reabsorption of glucose in the renal tubules. This action has garnered considerable attention for Empagliflozin in the field of diabetes treatment.

      First and foremost, Empagliflozin exerts its effects in treating diabetes by inhibiting SGLT-2. Under normal circumstances, SGLT-2 assists the kidneys in reabsorbing glucose from urine, returning it to the bloodstream. However, in patients with diabetes, high blood sugar levels prevent the complete reabsorption of glucose by the renal tubules, leading to the excretion of a significant amount of glucose in the urine. Empagliflozin's action involves slowing down the reabsorption of glucose by inhibiting SGLT-2, promoting the excretion of excess glucose through urine, thereby lowering blood sugar levels and aiding diabetes patients in glycemic control.

      Furthermore, Empagliflozin may have positive effects on weight management and cardiovascular health. Its characteristic of promoting the excretion of excess glucose through urine could potentially lead to a reduction in the caloric burden within the body, contributing to weight loss. Additionally, some studies suggest that Empagliflozin may have a protective effect on the cardiovascular system, slowing down the development of cardiovascular complications.

      It is noteworthy that Empagliflozin's selective inhibition of SGLT-2 avoids interference with SGLT-1, primarily found in the intestines and crucial for glucose absorption. This selectivity helps minimize blood glucose levels while reducing its impact on the gastrointestinal system.

      In conclusion, Empagliflozin, as an SGLT-2 inhibitor, offers unique advantages in the treatment of diabetes. By regulating the excretion of glucose in urine, it has the potential to assist patients in better managing their blood sugar levels, with possible additional benefits such as weight reduction and cardiovascular protection. As research delves deeper into its mechanisms of action and clinical effects, Empagliflozin is poised to play an increasingly important role in diabetes treatment.

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    How to buy  Tofacitinib CAS 477600-75-2?

    Wuhan Comings Biotechnology Co., Ltd. Produce Tofacitinib  have successfully penetrated both domestic and international markets, earning widespread recognition and trust. We deeply understand that different markets and customers have their unique requirements. Hence, we offer various packaging options to cater to personalized needs. Whether in domestic or international markets, we always prioritize quality, striving to provide exceptional products and services to our customers. Our products not only uphold high quality but also offer diverse packaging specifications to meet the specific needs of different customers, setting us apart in the industry.


    Buy 99% pure Ezetimibe ,please contact Wuhan Comings Biotechnology Co., Ltd.

    Whatsapp:008615871455372


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    Basic Info
    Product Name:

    Tofacitinib

    Other Name:

    1-Piperidinepropanenitrile,4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-,(3R,4R)-;3-Piperidinamine,1-(cyanoacetyl)-4-methyl-N-methyl-N-1H-pyrrolo[2,3-d]pyrimidin-4-yl-,(3R,4R)-;(3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile;CP 690550;Tofacitinib;2097815-04-6

    CAS No.:

    477600-75-2

    Molecular Formula:

    C16H20N6O

    InChIKeys:

    InChIKey=UJLAWZDWDVHWOW-YPMHNXCESA-N

    Molecular Weight:

    312.3696

    Exact Mass:

    312.37

    EC Number:

    1806241-263-5

    UNII:

    87LA6FU830

    DSSTox ID:

    DTXSID90197271

    NCI Thesaurus Code:

    C95800

    Color/Form:

    Yellow foam

    ATC Code:

    L04AA29|L - Antineoplastic and immunomodulating agents

    HScode:

    29335990

    Characteristics
    PSA:

    88.9

    XLogP3:

    1.5

    Density:

    1.3±0.1 g/cm3

    Melting Point:

    White crystalline solid. MP: 199-206 °C /Tofacitinib monocitrate/

    Boiling Point:

    585.845ºC at 760 mmHg

    Flash Point:

    308.1±30.1 °C

    Refractive Index:

    1.646

    Water Solubility:

    In water, 155.1 mg/L at 25 deg C (est)

    Storage Conditions:

    Keep container tightly closed in a dry and well-ventilated place. /Tofacitinib citrate/

    Vapor Pressure:

    1.32X10-10 mm Hg at 25 deg C (est)

    Specific rotation:

    Specific optical rotation: +10.4 deg at 25 °C/D (c = 0.64 in methanol)

    Henrys Law Constant:

    Henry's Law constant = 3.17X10-21 atm-cu m/mol at 25 °C (est)

    Dissociation Constants:

    pKa1 = 8.46 (cyano); pKa2 = 13.56 (secondary amine)

    Experimental Properties:

    Hydroxyl radical reaction rate constant = 2.57X10-10 cu cm/molec-sec at 25 °C (est)

    Hazard Identification

    Classification of the substance or mixture

    Not classified.

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H301 Toxic if swallowed

    H311 Toxic in contact with skin

    H315 Causes skin irritation

    H319 Causes serious eye irritation

    H331 Toxic if inhaled

    H335 May cause respiratory irritation

    Precautionary statement(s)
    Prevention

    none

    Response

    none

    Storage

    none

    Disposal

    none

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    semaglutide,tirzepatide,Liraglutide,Retatrutide,5-amino-1MQ,SLU-PP-332

    Location:

    No. 1, 19th Floor, Unit 2, Building 5, Southeast Residential Building (Hankou Yujiang Lanting), at the intersection of Hanshi Highway and Fufa South Road, Wuhu Street, Huangpi District, Wuhan City, Hu

    Payment Terms:

    TT against copy of documents,100% TT in advance

    Average lead Time:

    15

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2023

    We prospectively allocates international cutting-edge production and testing equipment and environmental protection facilities. The 5 production lines can achieve an annual output of 1000Kg. We to be the best chemical manufacture in China,and will become a trustworthy supplier of chemicals for global customers.
    Our main products include peptides, cognitive enhancers, pharmaceutical intermediates, and botanical extracts.
    And our main clients cover: pharmaceutical companies, hospitals, laboratories in higher education institutions, and cosmetic companies.
    Since its establishment, our company's products have been exported to regions including Europe, the Americas, the Middle East and so on. Our commitment to high product quality and excellent after-sales service has provided customers with a positive experience.
    Wuhan Comings Biotechnology Co., Ltd. is looking forward to cooperating with you with professional knowledge, high-quality service and competitive price!
  • Inquiry History
    2 Inquiries
    Country Product Purchase Quantity Date Posted
    United States

    tofacitinib Factory Price 99% pure CAS 477600-75-2 tofacitinib powder

    100 G Aug 6, 2023
    Canada

    Tofacitinib

    10 G Nov 28, 2025
    Post an enquiry for this product
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