104121-92-8 | ChemExpress
104121-92-8
shanghai
10 kg
2024-04-01
CRO
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceEldecalcitol (Edirol) was approved in January 2011 by the Japanese Ministry of Health, Labor, and Welfare for the treatment of osteoporosis. Because of vitamin D’s central role in the bone health, vitamin D and analogs of vitamin D have been used to treat patients diagnosed with osteoporosis. Eldecalcitol is an analog of the active form of vitamin D, calcitriol, in which the lower cyclohexane ring contains a hydroxypropyl group. The synthesis of eldecalcitol involves the assembly of two units, a fully protected (3S,4S,5R)-oct-1-en-7-yne-3,4,5-triol and a fused bicyclic system, (R)-6- ((1R,3aR,7aR,E)-4-(bromomethylene)-7a-methyloctahydro-1H-inden-1- yl)-2-methylheptan-2-ol, through a Diels-Alder reaction to give fully protected eldecalcitol. The hydroxyl groups are then deprotected to give the parent molecule. Eldecalcitol binds to the vitaminDreceptor 2.7-fold more potently than calcitriol, while only weakly inhibiting serum parathyroid hormone.
ChEBI: A hydroxycalciol that is calcitriol with a 3-hydroxypropoxy group at position 2.Basic Info-
Product Name:
2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3
Other Name:2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3;Eldecalcitol;ED-71;(1R,Z)-5-((E)-2-((1R,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-2-(3-hydroxypropoxy)-4-methylenecyclohexane-1,3-diol;1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3;Eldecalcitol(ED-71);2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitaMin D3;(1S,2S,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-(3-hydroxypropoxy)-4-methylidenecyclohexane-1,3-diol
CAS No.:104121-92-8
Molecular Formula:C30H50O5
InChIKeys:FZEXGDDBXLBRTD-AYIMTCTASA-N
Molecular Weight:490.71
EC Number:686-849-3
Color/Form:White to off-white
Categories:
Characteristics-
Density:
1.10
Melting Point:126-128℃
Boiling Point:655.7±55.0 °C(Predicted)
PKA:13.80±0.60(Predicted)
Critical Temperature & Pressure:Store at -20°C
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Seller Information
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Business Type:
Manufactory
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Main Products:
CRO
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Location:
1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA
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Payment Terms:
TT against copy of documents
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Average lead Time:
3 days
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
Above 1000
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Year of Establishment:
2006
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