Best Quality Nifuratel CAS NO (4936-47-4) Available At Best Selling price

Nifuratel (4936-47-4)

1. Chemical Identity: Nifuratel is a synthetic nitrofuran derivative with the chemical formula C8H6N4O5 and the CAS number 4936-47-4. It belongs to the class of nitrofuran antibiotics and is characterized by its nitrofuran core, which consists of a furan ring with a nitro group attached, and additional functional groups contributing to its pharmacological properties.

2. Synthesis: Nifuratel is synthesized through the reaction of 5-nitro-2-furaldehyde with ethyl acetoacetate and ammonium acetate under controlled conditions. The synthetic route may involve multiple steps, including condensation, cyclization, and nitration reactions, to yield the final product, nifuratel.

3. Pharmacological Activity: Nifuratel exhibits antibacterial and antiprotozoal activity against a broad spectrum of pathogens, including bacteria and parasites. It functions by inhibiting microbial DNA synthesis and disrupting essential cellular processes, ultimately leading to microbial cell death.

4. Therapeutic Uses: Nifuratel is primarily used for the treatment of various infections, including bacterial vaginosis, trichomoniasis, and urinary tract infections (UTIs). It is effective in eradicating the causative pathogens and alleviating symptoms associated with these infections.

5. Administration: Nifuratel is typically administered orally in the form of tablets or capsules. The dosage and duration of treatment may vary depending on the type and severity of the infection, as well as the patient's age, weight, and medical history.

6. Safety Profile: Nifuratel is generally well-tolerated, with adverse effects being relatively uncommon. However, it may cause gastrointestinal disturbances such as nausea, vomiting, and diarrhea in some individuals. Allergic reactions are rare but can occur in sensitive individuals.

7. Resistance and Sensitivity: Prolonged or indiscriminate use of nifuratel can contribute to the development of microbial resistance. Therefore, it is essential to use this medication judiciously and according to prescribed guidelines to minimize the risk of resistance emergence and preserve its effectiveness.

8. Pediatric and Special Populations: Nifuratel is suitable for use in pediatric patients, although dosing adjustments may be necessary based on the child's age and weight. Special caution is warranted in pregnant and breastfeeding women, and the medication should be used only if the potential benefits outweigh the risks.

9. Regulatory Approval and Availability: Nifuratel may be available under different brand names in various countries, and its availability may vary depending on local regulatory approvals and marketing authorizations. It is typically obtained through prescription from a qualified healthcare professional.

10. Future Perspectives: Continued research on nifuratel and its derivatives may focus on optimizing its pharmacokinetic properties, improving its spectrum of activity, and minimizing potential adverse effects. Additionally, efforts to combat microbial resistance and ensure appropriate antibiotic stewardship are crucial for preserving the efficacy of nifuratel and other antibacterial agents in clinical practice.