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METHYLDOPA.

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Unit Price:

$60-75/KG FOB

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CAS No.:

555-30-6

Content:

99%

Port:

ANY PORT IN CHINA

Packaging:

25KG/DRUM

Price valid (until):

2029-12-31

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Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

D-Biotin,Tobramycin base,L(-)-Carnitine base,Polymyxin B sulfate USP,Kanamycin sulfate monohydrate,Finasteride 99% USP

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Methyldopa, Antihypertensive agents, alpha-agonists, commonly used in tablet form. This product is a kind of stimulation of vascular motor center α-receptor, thereby inhibiting the foreign sensory nerve, resulting in antihypertensive effect, accompanied by slowing heart rate, reducing cardiac output, arteriolar dilation, peripheral vascular resistance is significantly reduced, long-term use of cardiac output is not significantly reduced. It is clinically used for moderate, severe or malignant hypertension, especially for secondary hypertension, pregnancy hypertension, heart failure complicated with hypertension, coronary heart disease complicated with hypertension and elderly patients with hypertension.

Basic Info

Product Name:

Methyldopa

Other Name:

L-Tyrosine,3-hydroxy-α-methyl-;Alanine,3-(3,4-dihydroxyphenyl)-2-methyl-,L-;3-Hydroxy-α-methyl-L-tyrosine;MK 351;Nr.C 2294;Aldomet;Levo-3-(3,4-Dihydroxyphenyl)-2-methylalanine;L-(-)-β-(3,4-Dihydroxyphenyl)-α-methylalanine;L-α-Methyl-3,4-dihydroxyphenylalanine;L-(-)-α-Methyl-β-(3,4-dihydroxyphenyl)alanine;Methyldopa;α-Methyl-L-3,4-dihydroxyphenylalanine;Presinol;(-)-α-Methyl-3,4-dihydroxyphenylalanine;l-3-(3,4-Dihydroxyphenyl)-2-methylalanine;Dopegyt;α-Methyldopa;(-)-Methyldopa;l-α-Methyldopa;α-Methyl-L-dopa;(S)-(-)-α-Methyldopa;L-2-Amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic acid;AMD;Aldometil;Aldomin;Dopamet;Sembrina;Dopatec;Medomet;Medopren;Methoplain;Alpha medopa;Bayer 1440L;Baypresol;Presolisin;Alphamethyldopa;2-Methyl-3-(3,4-dihydroxyphenyl)alanine;(-)-α-Methyldopa;L-3,4-Dihydroxyphenyl-2-methylalanine;(S)-α-Methyldopa;Methyl-L-dopa;L-α-Methyldopa;L-3,4-Dihydroxy-α-methylphenylalanine;L-Methyldopa;L-α-Methyl-3-(3,4)-dihydroxyphenylalanine;Equibar;Aldomine;Medopa;Lederdopa;Elanpres;NSC 169916;Aldochlor;(2S)-2-Amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;133161-54-3;779-08-8;1339-75-9;4290-08-8;88620-56-8

CAS No.:

555-30-6

Molecular Formula:

C10H13NO4

InChIKeys:

InChIKey=CJCSPKMFHVPWAR-JTQLQIEISA-N

Molecular Weight:

211.21

Exact Mass:

211.21

EC Number:

209-089-2

UNII:

M4R0H12F6M

NSC Number:

760080

DSSTox ID:

DTXSID5020863|DTXSID5023295

Color/Form:

Minute, anhyd crystals from methanol|WHITE TO YELLOWISH WHITE, FINE POWDER, WHICH MAY CONTAIN FRIABLE LUMPS

ATC Code:

C - Cardiovascular system

HScode:

2918199090

Categories:

Nervous System Drugs

Characteristics

PSA:

104

XLogP3:

-1.79

Appearance:

Methyl dopa appears as colorless or almost colorless crystals or white to yellowish-white fine powder. Almost tasteless. In the sesquihydrate form. pH (saturated aqueous solution) about 5.0. (NTP, 1992)

Density:

1.4±0.1 g/cm3

Melting Point:

300 °C (decomp)

Boiling Point:

441.6±45.0 °C at 760 mmHg

Flash Point:

220.9±28.7 °C

Refractive Index:

1.635

Water Solubility:

H2O: 10g/L(temperature not stated)

Storage Conditions:

Store at RT

Toxicity:

LD50 oral in rabbit: 713mg/kg

Specific rotation:

Max absorption: 281 nm (e= 2780); Specific optical rotation (1 in 0.1 N HCl): -4.0 +/- 0.5 deg @ 23 °C/D

Odor:

ODORLESS

Taste:

ALMOST TASTELESS

PH:

pH of saturated aq soln about 5.0

Collision Cross Section:

147.6 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|146.8 Å² [M+Na]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Experimental Properties:

Considerably hygroscopic; decomp @ approx 300 °C; exists as sesquihydrate|Crystals from water /sesquihydrate/

Air and Water Reactions:

Very hygroscopic. Slightly water soluble. May be sensitive to prolonged exposure to air and light. The stability of aqueous solutions is markedly dependent on pH, oxygen and the amount of initial reactant. Aqueous solutions are stable for up to 50 hours in acid and neutral pH (6.2). At pH 8.0, decomposition products are formed in 3 to 5 hours. Solutions develop a red tint that becomes progressively darker (eventually forming a black precipitate).

Reactive Group:

Acids, Carboxylic

Reactivity Profile:

METHYL DOPA undergoes catalytic oxygenation in the presence of magnesium, cupric, cobalt, nickel and ferric ions (NTP, 1992). A weakly acidic amino acid.

See More Methyldopa Properties 

Hazard Identification

Classification of the substance or mixture

Reproductive toxicity, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H361 Suspected of damaging fertility or the unborn child
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Methyldopa oral suspension should be stored in tight, light-resistant containers at a temperature less than 26 deg C and protected from freezing. Methyldopa tablets should be stored in well-closed containers at a temperature less than 40 deg C, preferably at 15-30 deg C.

See More Methyldopa Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
D-Biotin,Tobramycin base,L(-)-Carnitine base,Polymyxin B sulfate USP,Kanamycin sulfate monohydrate,Finasteride 99% USP

Location:
1613 Guangyin Building,No.42 E.Fengqi Road,Hangzhou,310012 China.

Payment Terms:
TT against copy of documents,L/C

Average lead Time:
7

Total Annual Revenue:
$25 million-$50 million

Total Employees:
11-50

Year of Establishment:
2011

Dawn Ray is a R&D and process improvement company,which is located in Hangzhou, Zhejiang province,China.We are dealing in multi-application of pharmaceuticals(APIs),antibiotics,food additives,peptides and plant extracts.

Dawn Ray has a wide range of products from milligram up to thousands of kilogram quantities.We are also increasing our breed all the time.Our products have been exported all over the world and have a good reputation.

Dawn Ray promises that we can offer you qualified products and excellent service in good prices.Our aim is "Best goods,best service".We sincerely invite customers from all over the world to visit our company,establish business relations and both get win.

Process Capacity: Synthetic,Ferment,extract

After-sale Service:24 hours on skype for business

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
Pakistan	Methyldopa	2000 KG	Sep 13, 2023
Pakistan	Methyldopa	75 KG	Sep 11, 2023

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METHYLDOPA.

Product Description

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