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API Tobramycin CAS 32986-56-4

Name: API Tobramycin CAS 32986-56-4
Brand: Hyper Chem
SKU: pr2410221093
Price: 930 USD
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CAS No.:

32986-56-4

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

Hyper Chem

Packaging:

20kg/Drum,25kg/Drum

Price valid (until):

2024-11-22

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Tobramycin
CAS number	32986-56-4
Related CAS	32986-56-4 (free base) 79645-27-5 (sulfate deleted) 49842-07-1 (sulfate)
Description	Tobramycin is an effective antibiotic commonly used in the management and treatment of various systemic and ocular infections. As an aminoglycoside antibiotic, tobramycin is active against aerobic gram-negative bacteria, including Pseudomonas aeruginosa. Tobramycin binds to the 16s ribosomal RNA component of the bacterial 30s ribosomal unit, inhibiting the initiation step of translation. By binding to the A-site, tobramycin induces mistranslation and causes transfer RNA to misread the codon, thus causing incorrect delivery of aminoacyl units. Incorrectly synthesized proteins build up inside the cell, disrupting the cell membrane and various cellular processes; this mechanism of action designates tobramycin as a bactericidal agent.
Structure
Molecular Formula	C₁₈H₃₇N₅O₉
Molecular Weight	467.520
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 – 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Tobramycin More Info

Tobramycin is an antibiotic medication that is primarily used for the treatment of various bacterial infections. It belongs to the aminoglycoside class of antibiotics.

Medical Uses

Tobramycin is primarily indicated for:

- Severe bacterial infections: Such as pneumonia, urinary tract infections, bloodstream infections, and complicated intra-abdominal infections caused by susceptible bacteria.

- Cystic fibrosis-related lung infections: It is often used in the management of lung infections in patients with cystic fibrosis.

Administration and Dosage

Tobramycin is available in injectable form and is usually administered intravenously or intramuscularly. The dosage depends on the severity of the infection, the patient's weight, and kidney function. Typically, it is administered in divided doses several times a day.

Side Effects and Precautions

Common side effects may include kidney damage, hearing loss, dizziness, and nausea. Due to its potential toxicity, close monitoring of kidney function and hearing is essential during treatment. It is contraindicated in patients with known hypersensitivity to aminoglycosides. Pregnant women and nursing mothers should use it with caution as it may pose risks to the fetus or infant.

Overall, tobramycin is a valuable antibiotic for treating serious bacterial infections, but its use requires careful consideration of potential side effects and close monitoring by healthcare providers.

ECHEMI Editorial Reference

Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius.Target: AntibacterialTobramycin is an aminoglycoside antibiotic derived from Streptomyces tenebrarius and used to treat various types of bacterial infections, particularly Gram-negative infections. It is especially effective against species of Pseudomonas [1]. Tobramycin works by binding to a site on the bacterial 30S and 50S ribosome, preventing formation of the 70S complex. As a result, mRNA
Solid
Tobramycin is a amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring. It has a role as an antibacterial agent, an antimicrobial agent and a toxin. It derives from a kanamycin B. It is a conjugate base of a tobramycin(5+).|An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is a 10% component of the antibiotic complex, nebramycin, produced by the same species.|Tobramycin is an Aminoglycoside Antibacterial.|Tobramycin is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms. Despite its wide use, tobramycin has rarely been linked to instances of clinically apparent liver injury.|Tobramycin is an aminoglycoside antibiotic derived from Streptomyces tenebrarius with bacteriostatic activity. Following active transport into the cell, tobramycin binds irreversibly to a specific aminoglycoside receptor on the bacterial 30S ribosomal subunit and interferes with the initiation complex between messenger RNA and the 30S subunit, thereby inhibiting initiation of protein synthesis, consequently leading to bacterial cell death. In addition, tobramycin induces misreading of the mRNA template causing incorrect amino acids to be incorporated into the growing polypeptide chain, consequently interfering with protein elongation.|An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.

Certificates

Basic Info

Product Name:

Tobramycin

Other Name:

D-Streptamine,O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-;O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-D-streptamine;Nebramycin factor 6;Tobramycin;3′-Deoxykanamycin B;Nebramycin 6;Nebramycin VI;Deoxykanamycin B;Tobramycetin;Tobramicin;Tobralex;Tobrex;Tobramaxin;NF 6;Tobradistin;Tobracin;NSC 180514;Tobramax;Tobrin;Vantobra;Tobi Podhaler;11098-01-4;11111-45-8;34337-51-4;37321-13-4;54330-95-9;70322-33-7

CAS No.:

32986-56-4

Molecular Formula:

C18H37N5O9

InChIKeys:

InChIKey=NLVFBUXFDBBNBW-PBSUHMDJSA-N

Molecular Weight:

467.51

Exact Mass:

467.51

EC Number:

251-322-5

UNII:

VZ8RRZ51VK

NSC Number:

757352

DSSTox ID:

DTXSID8023680

NCI Thesaurus Code:

C62082

Color/Form:

White to off-white powder|Crystals

ATC Code:

J01GB01|J - Antiinfectives for systemic use|S - Sensory organs

HScode:

29419090

Categories:

Antibiotics

Characteristics

PSA:

268

XLogP3:

-6.2

Appearance:

white to off-white

Density:

1.5±0.1 g/cm3

Melting Point:

164 °C

Boiling Point:

741.6°C at 760 mmHg

Flash Point:

422.8±32.9 °C

Refractive Index:

1.651

Water Solubility:

H2O: 50 mg/mL, clear, faintly yellow

Storage Conditions:

2-8°C

Vapor Pressure:

2.37X10-21 mm Hg at 25 deg C (est)

Toxicity:

LD50 in mice, rats (mg/kg): 441, 969 s.c. (Welles)

Specific rotation:

D20 +129° (c = 1 in water)

PH:

Basic substance

Henrys Law Constant:

Henry's Law constant = 2.24X10-39 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

pKb1 = 8.6; pKb2 = 8.8; pKb3 = 9.0 (amines) (est)

Experimental Properties:

Hygroscopic

See More Tobramycin Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Tobramycin Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Company Certificates
- Certification Report by Bureau Veritas
About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

5 Inquiries

Country	Product	Purchase Quantity	Date Posted
Bulgaria	Tobramycin powder CAS 32986-56-4	50 G	Oct 22, 2024
India	Tobramycin	5 MT	Nov 14, 2025
Pakistan	Tobramycin	1 KG	Mar 6, 2025
Pakistan	Tobramycin	2	Feb 23, 2024
Bangladesh	Tobramycin	1 KG	Apr 13, 2026

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API Tobramycin CAS 32986-56-4

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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