API Flunixin meglumine

Name	Flunixin meglumine
CAS number	42461-84-7
Synonym	Flunixin meglumine; Banamine; Flumeglumine; Flunixin-S
Description	Flunixin meglumine is a nonsteroidal anti-inflammatory drug used in many species for pain management.
Structure
Molecular Formula	C21H28F3N3O7
Molecular Weight	491.460
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 – 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>3 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Flunixin Meglumine More Info

Flunixin Meglumine is a non - steroidal anti - inflammatory drug (NSAID) with significant importance in veterinary medicine.

Chemical Structure and Properties

Flunixin Meglumine is the meglumine salt of flunixin. Its chemical structure allows it to have good solubility and stability in aqueous solutions. The molecule is designed to interact with specific target sites in the body to exert its pharmacological effects. It is usually a white to off - white crystalline powder and is soluble in water and some polar solvents.

Mechanism of Action

The drug works by inhibiting the cyclooxygenase (COX) enzyme, specifically COX - 1 and COX - 2. By blocking these enzymes, it reduces the production of prostaglandins. Prostaglandins are involved in the inflammatory process, pain perception, and fever. Flunixin Meglumine's ability to inhibit prostaglandin synthesis helps to alleviate pain, reduce inflammation, and lower fever. For example, in cases of acute inflammation, such as post - surgical inflammation or inflammation due to injury, it can prevent the over - production of prostaglandins that would otherwise exacerbate pain and swelling.

Applications in Veterinary Medicine

Pain Management

In livestock and horses, it is widely used for pain relief. For example, in cattle after dehorning or castration, Flunixin Meglumine can effectively reduce the pain associated with these procedures. In horses, it is used to manage pain caused by musculoskeletal injuries, such as tendonitis or laminitis. It provides relief and allows the animals to move more comfortably, which is crucial for their recovery.

Fever Reduction

It is also used to treat fever in animals. In cases of infectious diseases where fever is a symptom, such as in swine influenza or bovine viral diarrhea, Flunixin Meglumine can help to bring down the body temperature and reduce the associated malaise and discomfort.

Inflammatory Conditions

For inflammatory conditions like mastitis in dairy cows, it can reduce the inflammation in the udder. By decreasing the inflammatory response, it helps to improve milk quality and the overall health of the affected udder. In poultry, it can be used to manage inflammatory responses associated with respiratory infections.

Dosage and Administration

The dosage of Flunixin Meglumine varies depending on the species, body weight, and the nature of the condition being treated. It can be administered intravenously, intramuscularly, or subcutaneously. In some cases, oral formulations may also be available. The intravenous route provides the fastest onset of action, usually used in acute and severe cases. When administering, it is essential to calculate the correct dose to avoid under - dosing (which may lead to ineffective treatment) or over - dosing (which can cause toxicity).

Precautions and Side Effects

Some animals may experience side effects such as gastrointestinal disturbances, including vomiting, diarrhea, or inappetence. There is also a risk of renal toxicity if used at high doses or for an extended period. In pregnant animals, it should be used with caution as it may have potential effects on the fetus. Additionally, care should be taken when combining Flunixin Meglumine with other NSAIDs or certain medications, as drug - drug interactions may occur, potentially increasing the risk of adverse effects.