High Quality USP White Powder Clindamycin phosphate CAS 24729-96-2

Clindamycin phosphate More Info

Clindamycin phosphate is a phosphate ester of clindamycin, a lincosamide antibiotic, used primarily in topical formulations for the treatment of various bacterial infections, particularly acne. 

Mechanism of Action

Clindamycin phosphate is converted in vivo to its active form, clindamycin, which inhibits bacterial protein synthesis. It does this by binding to the 23S rRNA of the 50S ribosomal subunit, preventing peptide bond formation and inhibiting ribosomal translocation. This action can be bacteriostatic or bactericidal depending on the drug concentration and the specific organism involved. Resistance to clindamycin can occur through mutations in the ribosomal RNA or through cross-resistance with other antibiotics like macrolides and streptogramins due to overlapping binding sites.

Applications

Acne Vulgaris: It is commonly used in topical formulations to reduce acne lesions.
Bacterial Infections: Effective against anaerobic bacteria and certain gram-positive organisms.
Skin Infections: Used for treating skin infections caused by susceptible bacteria.

Routes of Administration

Topical Gel/Lotion/Solution: Applied directly to the affected skin areas for treating acne.
Intramuscular/Intravenous Forms: Clindamycin phosphate can also be administered parenterally in hospital settings for severe infections.

Safety and Side Effects

While clindamycin phosphate is generally well-tolerated, it can cause several side effects:
Common Side Effects: Skin irritation, burning or itching at the application site, dryness, redness, and peeling skin.
Serious Risks: There is a risk of Clostridium difficile-associated diarrhea (CDAD), which can lead to pseudomembranous colitis. Symptoms include severe diarrhea, abdominal pain, and blood or mucus in stools.
Allergic Reactions: Rarely, serious allergic reactions such as rash, difficulty breathing, or swelling may occur.
Patients should be advised to report any severe gastrointestinal symptoms or signs of an allergic reaction immediately.

Pharmacokinetics

Absorption
Clindamycin phosphate itself is inactive until converted to clindamycin after systemic absorption. Following topical application, very low serum levels of clindamycin are observed (0–3 ng/mL), indicating minimal systemic absorption.
Distribution
Once converted to clindamycin, it distributes widely in body tissues. High concentrations are achieved in bones and soft tissues but not in the central nervous system.
Metabolism
Clindamycin is primarily metabolized by the liver via cytochrome P450 enzymes (mainly CYP3A4). The phosphate form serves as a prodrug that rapidly converts to active clindamycin upon administration.
Elimination
The elimination half-life of clindamycin ranges from 2 to 4 hours. Approximately 10% of the drug is excreted unchanged in urine; most is eliminated as inactive metabolites in feces. The rapid elimination of clindamycin phosphate occurs within 1.5 hours post-administration.
Special Considerations
Caution should be exercised when using clindamycin phosphate in patients with a history of gastrointestinal disorders due to the risk of colitis. Additionally, dosage adjustments may be necessary for patients with hepatic impairment.

Package Image

FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.