raw material Acetamidine hydrochloride

Acetamidine hydrochloride More Info

Physical Properties

Appearance: Colorless to white long prismatic crystals

Melting Point: 164–166°C or 165-170°C

Boiling Point: 62.8°C at 760 mmHg

Flash Point: 26.1°C

Refractive Index at 20°C: 1.458

Density: 1.03 g/cm³

Solubility in Water: 1 g/mL (very soluble)

Additional Solubility: Soluble in alcohol, ethanol, and methanol; nearly insoluble in ether and acetone

Vapor Pressure: 176 mmHg at 25°C

Chemical Properties

The compound is hygroscopic and forms colorless monoclinic crystals. Upon heating, it releases ammonium chloride. In aqueous solutions, it hydrolyzes to acetic acid and ammonia. When exposed to alkaline solutions, free acetamidine is liberated, and slight heating causes decomposition into ammonia and acetic acid. The maximum absorption wavelength is 224 nm.

Specifications

Assay (GC): 91% minimum

Water content (KF): 1% maximum

Ammonium Chloride: 5% maximum

Available Purity Grades: 97%, 98%

Applications

Pharmaceutical Development: Acetamidine hydrochloride serves as a building block in the synthesis of various pharmaceuticals, particularly in the development of analgesics and anti-inflammatory drugs. It has been used in the preparation of decarboxyectoine and ethyl 4-(4-hydroxyphenyl)methylidene-2-methyl-5-oxo-1-imidazolacetate.

Synthesis of Antibiotics and Vitamins: The compound is used for synthesizing imidazole, pyrimidine, and triazine antibiotics, as well as for the synthesis of vitamin B₁.

Agricultural Chemicals: It is used in formulating agrochemicals, enhancing crop protection products by acting as an intermediate in the synthesis of pesticides.

Biochemical Research: Researchers employ acetamidine hydrochloride in studies related to enzyme inhibition and protein interactions, aiding in the understanding of biochemical pathways.

Analytical Chemistry: This compound is utilized as a reagent in analytical methods, including chromatography, to improve the detection and quantification of various substances.

Material Science: It finds applications in the development of polymers and other materials, contributing to innovations in coatings and adhesives.

Preparation Method

The compound is produced by the addition and amination reaction of acetonitrile, hydrochloric acid, and methanol. The preparation involves reacting these components with cooling to separate acetamidine hydrochloride in long colorless prisms.

Safety Profile

Acetamidine hydrochloride is a stimulant substance that may cause irritation upon contact. The hazard statement indicates it is irritant. Safety measures recommend avoiding eye contact. When handling the compound, protective clothing, gloves, and eye protection should be worn.

Storage and Handling

The compound should be stored in a cool and dry place. It is hygroscopic and should be kept in a tightly stoppered bottle. The substance should be stored away from oxidizing agents. The recommended packaging is fiber drums lined with polyethylene film bags, with each bag containing 25 kg.

Regulatory Information

Products are labeled for research and development use only. They are not intended for medicinal, household, or other uses. All products are intended for industrial applications or scientific research purposes only and are not suitable for clinical diagnosis or treatment of humans or animals.

Packaging Options

25 kg fiber drum

Shipping Capacity: 1*20'FCL can load 10 mt without pallets or 9 mt with pallets

Sample Sizes: Various sample sizes available (e.g., 1 g, 5 g)