High Quality 50% & 95% Purity White Powder Natamycin CAS 7681-93-8 Food Preservative

Natamycin More Info

Natamycin, also known as pimaricin, is a macrolide antifungal medication primarily used to treat fungal infections, particularly in the ophthalmic field. 

Mechanism of Action

Natamycin exerts its antifungal effects through the following mechanisms:
Binding to Ergosterol: Natamycin specifically binds to ergosterol, a key sterol component of fungal cell membranes. This binding disrupts the integrity of the membrane, leading to impaired cell function.
Inhibition of Nutrient Transport: By binding to ergosterol, natamycin inhibits amino acid and glucose transport proteins in the fungal plasma membrane. This results in a loss of nutrient transport and ultimately contributes to cell death.
Fungicidal Activity: Natamycin exhibits fungicidal properties against a wide range of fungi, including yeasts and filamentous fungi such as Candida, Aspergillus, Fusarium, and Penicillium species.

Applications

Natamycin is primarily used for:
Ophthalmic Infections: It is approved for treating fungal infections around the eye, including:
Mycotic Keratitis: An infection of the cornea.
Fungal Blepharitis: Infection of the eyelids.
Fungal Conjunctivitis: Infection of the conjunctiva.
Food Preservation: Natamycin is also used as a food preservative due to its antifungal properties, particularly in dairy products and processed foods.

Routes of Administration

Natamycin can be administered through several routes:
Topical Ophthalmic Administration: The primary route for treating eye infections. It is usually provided as a 5% suspension that is instilled into the conjunctival sac.
Food Additive: Used as a preservative in food products; however, it is not indicated for oral administration in humans.

Safety and Side Effects

Natamycin is generally considered safe; however, some potential side effects may include:
Local Reactions: Common side effects include ocular irritation, foreign body sensation, lacrimation (tearing), and blurred vision.
Allergic Reactions: Some patients may experience hypersensitivity reactions such as itching or redness.
Limited Systemic Toxicity: Natamycin has low systemic toxicity due to minimal absorption when administered topically. In animal studies, high doses did not show significant toxicity.

Pharmacokinetics

The pharmacokinetics of natamycin include several important characteristics:
Absorption: Following topical application to the eyes, natamycin produces therapeutic concentrations within the corneal stroma; however, systemic absorption is minimal.
Distribution: Natamycin does not significantly penetrate intraocular fluids based on animal studies. Concentrations in the aqueous humor are typically not measurable after topical administration.
Metabolism: Limited information is available regarding the metabolism of natamycin; it is primarily excreted unchanged.
Excretion: Natamycin is primarily excreted through feces when used as a food preservative. Following ophthalmic use, systemic absorption is not expected.

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FAQ

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We can send you a samll free sample, and you only need to pay for the shipping cost.

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Suitable for more than 50kg 
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