API Levomefolate calcium

Name	Levomefolate calcium
CAS number	151533-22-1
Synonym	BAY 86-7660; BAY-86-7660; BAY86-7660; BAY 867660; BAY-867660; BAY867660; Levomefolate calcium; LMCA; Bodyfolin, Deplin; L-Methylfolate calcium; Levomefolate calcium; Levomefolinate calcium
Related CAS	151533-22-1 (calcium)   31690-09-2 (free acid)   419563-18-1 (calcium pentahydrate)
Description	Levomefolate calcium, also known as LMCA and BAY 86-7660, is the calcium salt of 5-methyltetrahydrofolic acid, a biologically active form of folic acid that functions, in conjunction with Vitamin B12 , as a methyl-group donor involved in the conversion of homocysteine to methionine. Levomefolate is included in formulations of certain oral contraceptives to ensure adequate folic acid levels in women of child-bearing age to reduce the risk of neural tube defects.
Structure
Molecular Formula	C20H23CaN7O6
Molecular Weight	497.520
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 – 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Levomefolate Calcium More Info

Introduction to Levomefolate Calcium

Levomefolate calcium, also known as 5 - methyl - tetrahydrofolate calcium salt, is a vital nutrient. It is the active form of folic acid and is a member of the B - vitamin family. Unlike folic acid which requires conversion in the body, levomefolate calcium can be directly used by the body.

Biological Functions

Cell Division and Growth: Levomefolate calcium is indispensable for DNA synthesis and repair. It provides the necessary methyl groups for the production of thymidylate, a fundamental component of DNA. Inadequate amounts of levomefolate calcium can lead to abnormal cell division and growth. This is especially crucial during pregnancy for the proper development of the fetus. For example, a lack of this nutrient can result in neural tube defects in the fetus.

Methylation Reactions: It plays a central role in methylation reactions in the body. Methylation is a biochemical process that modifies DNA, proteins, and other biomolecules. These modifications can influence gene expression and a variety of physiological functions. Levomefolate calcium donates methyl groups, which are involved in processes such as neurotransmitter synthesis and detoxification reactions.

Red Blood Cell Formation: Levomefolate calcium works together with vitamin B12 to contribute to the formation of healthy red blood cells. A deficiency of levomefolate calcium can lead to megaloblastic anemia, a condition characterized by enlarged and abnormal red blood cells.

Sources and Supplements

Natural Sources: Leafy green vegetables such as spinach, broccoli, and asparagus are rich sources of levomefolate calcium. Legumes including lentils and chickpeas also contain a significant amount. Fruits like oranges and strawberries have a relatively smaller quantity of levomefolate calcium.

Supplements: For those who have difficulty obtaining enough levomefolate calcium from their diet, supplements are available. These supplements usually come in the form of levomefolate calcium capsules or tablets. Some multivitamin supplements also contain levomefolate calcium as an ingredient. It's important to note that the dosage of supplements should be carefully considered, as excessive intake of this nutrient can mask a vitamin B12 deficiency.

Absorption and Metabolism

Levomefolate calcium is absorbed in the small intestine through specific transporters. Once absorbed, it enters the bloodstream and is distributed to various tissues where it participates in metabolic processes. The liver plays a key role in metabolizing and storing this nutrient. The body carefully regulates the levels of levomefolate calcium to ensure its proper utilization and to prevent toxicity.