High Quality USP 99% Fluconazole CAS 86386-73-4 with Ready Stock and Fast Delivery

Fluconazole More Info

Fluconazole is a widely used antifungal medication belonging to the triazole class, primarily effective against various fungal infections. It is particularly noted for its efficacy against Candida species and Cryptococcus neoformans, making it a critical treatment option in clinical settings. 

Mechanism of Action

Fluconazole exerts its antifungal effects by selectively inhibiting the enzyme lanosterol 14-α-demethylase, a cytochrome P450 enzyme crucial for converting lanosterol to ergosterol, an essential component of the fungal cell membrane. This inhibition disrupts ergosterol synthesis, leading to increased membrane permeability and ultimately fungal cell death. The accumulation of toxic sterols in the fungal membrane contributes to its fungistatic activity, although at higher concentrations, fluconazole can exhibit fungicidal properties against certain fungi, particularly Cryptococcus species.

Applications

Fluconazole is indicated for the treatment of various fungal infections, including:
Candidiasis: Oropharyngeal, esophageal, and systemic candidiasis.
Cryptococcal Meningitis: Particularly in immunocompromised patients such as those with HIV/AIDS.
Histoplasmosis: As a second-line treatment.
Dermatophytosis: Including tinea infections.
Prophylaxis: In high-risk patients such as those undergoing chemotherapy or organ transplantation to prevent candidiasis.

Routes of Administration

Fluconazole can be administered via:
Oral Route: Highly bioavailable (>90%), making it suitable for outpatient treatment.
Intravenous Route: Used in cases where oral administration is not feasible due to gastrointestinal issues or severe infections.

Safety and Side Effects

Fluconazole is generally well-tolerated; however, some side effects can occur:
Common Side Effects: Nausea, vomiting, diarrhea, headache, and abdominal pain.
Serious Reactions: Hepatotoxicity (elevated liver enzymes), skin rashes (including Stevens-Johnson syndrome), and cardiac arrhythmias due to QT interval prolongation.
Drug Interactions: Fluconazole can inhibit cytochrome P450 enzymes (CYP2C19, CYP3A4), potentially increasing the plasma concentrations of other medications metabolized by these pathways.

Pharmacokinetics

Fluconazole exhibits favorable pharmacokinetic properties:
Absorption: Rapidly absorbed after oral administration with peak plasma concentrations occurring approximately 1-2 hours post-dose. Food does not significantly affect absorption.
Distribution: The volume of distribution is about 0.7 L/kg, with low plasma protein binding (approximately 12%). It penetrates well into various body fluids, including cerebrospinal fluid and urine134.
Metabolism: Minimal hepatic metabolism occurs; only about 10% is metabolized. The drug is primarily eliminated unchanged via renal excretion (approximately 80%).
Half-Life: The elimination half-life is approximately 30 hours, allowing for once-daily dosing in most cases. Steady-state concentrations are typically reached within 7 days of regular dosing.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
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By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

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