High Quality Ursodeoxycholic acid CAS 128-13-2 UDCA 99% Purity with good price and safe delivery

Ursodeoxycholic acid More Info

Ursodeoxycholic acid (UDCA) is a bile acid used primarily for its hepatoprotective effects and is indicated in the treatment of various liver disorders. It is particularly effective in managing primary biliary cholangitis and has been studied for its potential benefits in other hepatic conditions.

Mechanism of Action

Ursodeoxycholic acid exhibits several mechanisms that contribute to its therapeutic effects:
Choleretic Effect: UDCA promotes bile flow by increasing the secretion of bile acids from hepatocytes, enhancing the solubilization of cholesterol in bile, and reducing cholesterol absorption in the intestine.
Hepatoprotective Properties: It protects liver cells (hepatocytes) from damage caused by toxic bile acids, reactive oxygen species (ROS), and inflammation. This is achieved by stabilizing cell membranes and modulating apoptosis pathways.
Immunomodulatory Effects: UDCA may reduce the expression of major histocompatibility complex (MHC) class I antigens, suggesting it has immunosuppressive properties that can benefit autoimmune liver diseases.
Alteration of Bile Acid Composition: By displacing more toxic bile acids from the bile pool, UDCA changes the hydrophobicity index, making the bile less harmful to hepatocytes.

Applications

Ursodeoxycholic acid is used for:
Primary Biliary Cholangitis: It is the primary treatment for this chronic liver disease, helping to improve liver function and slow disease progression.
Gallstone Dissolution: UDCA can be used to dissolve cholesterol gallstones in patients who cannot undergo surgery.
Nonalcoholic Fatty Liver Disease (NAFLD): Its role in treating NAFLD remains under investigation, with some studies suggesting potential benefits.
Hepatoprotection: UDCA is being explored for its protective effects in various liver conditions, including those associated with alcohol use and metabolic disorders.

Routes of Administration

Ursodeoxycholic acid is administered orally. Typical dosages range from 10 to 15 mg/kg/day, depending on the condition being treated. It is available in tablet for

Safety and Side Effects

UDCA is generally well-tolerated; however, some side effects may include:
Common Side Effects: Diarrhea, constipation, nausea, and abdominal discomfort.
Serious Reactions: Rarely, it can cause elevated liver enzymes or allergic reactions.
Monitoring Requirements: Regular liver function tests are recommended to monitor for potential hepatotoxicity or other adverse effects.

Pharmacokinetics

Ursodeoxycholic acid has distinct pharmacokinetic characteristics:
Absorption: Approximately 90% of UDCA is absorbed from the gastrointestinal tract after oral administration. It undergoes enterohepatic circulation, where it is reabsorbed in the intestines and returned to the liver.
Distribution: The volume of distribution is not precisely defined but is expected to be small as it primarily accumulates in bile3. UDCA is at least 70% bound to plasma proteins.
Metabolism: After absorption, UDCA is conjugated with glycine or taurine in the liver. It may also undergo microbial metabolism in the intestine to lithocholic acid, which has limited solubility and is mostly excreted in feces.
Elimination: The primary route of elimination for UDCA is through feces; renal excretion plays a minor role. The estimated half-life ranges from 3.5 to 5.8 days.

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