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API Ondansetron Hydrochloride

Name: API Ondansetron Hydrochloride
Brand: Hyper Chem
SKU: pr2412181460
Price: 620 USD
Availability: InStock

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CAS No.:

103639-04-9

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

Hyper Chem

Packaging:

20kg/Drum 25kg/Drum

Price valid (until):

2025-01-18

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Ondansetron Hydrochloride
CAS number	103639-04-9
Synonym	GR 38032F; GR-38032F;GR38032F;GRC50775; GRC-50775; GRC 50775; SN307; Ondansetron HCl hydrate
Related CAS	99614-02-5 (free base) 99614-01-4 (HCl) 103639-04-9 (HCl hydrate),
Description	Ondansetron is a highly selective serotonin 5-HT3 receptor antagonist, with low affinity for dopamine receptors. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties. in vitro studies confirm that Ondansetron inhibits AChE and BChE by non-competitive and mixed inhibition, respectively, with IC50 values 33 µM (AChE) and 2.5 µM (BChE). Ondansetron showed activity for preventing of ovarian hyperstimulation syndrome.
Structure
Molecular Formula	C₁₈H₂₄ClN₃O₃
Molecular Weight	365.858
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 – 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Ondansetron hydrochloride More Info

1. General Information

Ondansetron hydrochloride is a widely used anti - emetic (a drug that helps prevent vomiting) drug. Chemically, it is a serotonin 5 - HT₃ receptor antagonist.

2. Mechanism of Action

It works by blocking the action of serotonin, a neurotransmitter, at the 5 - HT₃ receptors located in the chemoreceptor trigger zone (CTZ) and on the vagal nerve terminals in the gastrointestinal tract. When chemotherapy drugs, radiation therapy, or other stimuli trigger the release of serotonin from the enterochromaffin cells of the small intestine, it binds to 5 - HT₃ receptors. Ondansetron hydrochloride inhibits this binding, thereby reducing the stimulation of the vomiting center in the brain and alleviating nausea and vomiting.

3. Pharmacokinetics

Absorption: Ondansetron hydrochloride is well - absorbed from the gastrointestinal tract after oral administration. The bioavailability of the oral formulation is about 56 - 75%.

Distribution: It is widely distributed throughout the body and crosses the blood - brain barrier to reach the central nervous system (CNS), which is important for its anti - emetic effect on the CNS - mediated vomiting reflex.

Metabolism: It is metabolized mainly in the liver by cytochrome P450 enzymes, specifically CYP1A2, CYP2D6, and CYP3A4. The metabolites are then excreted through the kidneys and feces.

Excretion: Approximately 50 - 70% of the drug and its metabolites are excreted in the urine, and the rest in the feces.

4. Indications

Chemotherapy - Induced Nausea and Vomiting (CINV): It is highly effective in preventing acute CINV (occurring within 24 hours after chemotherapy) and can also help with delayed CINV (occurring more than 24 hours after chemotherapy). For example, in patients receiving highly emetogenic chemotherapy regimens such as cisplatin - based chemotherapy, ondansetron hydrochloride can significantly reduce the frequency and severity of vomiting.

Post - Operative Nausea and Vomiting (PONV): It is used to prevent and treat nausea and vomiting that may occur after surgery. In surgical settings such as abdominal surgeries or surgeries under general anesthesia, it can improve patient comfort and reduce the risk of complications related to vomiting, like aspiration pneumonia.

Radiation - Induced Nausea and Vomiting: It can also be beneficial for patients undergoing radiation therapy, especially when the radiation field includes the abdomen or the head and neck region.

5. Dosage and Administration

Oral : The oral dosage forms include tablets and orally disintegrating tablets. The dose usually ranges from 8mg to 24mg per day, depending on the indication and the patient's response. Orally disintegrating tablets are convenient for patients who have difficulty swallowing, such as the elderly or those with nausea that may make swallowing regular tablets challenging.

Intravenous (IV): In acute situations such as severe chemotherapy - induced vomiting or in the immediate postoperative period, IV administration may be preferred. The typical IV dose is 4mg - 8mg, which can be repeated as needed according to the patient's symptoms.

6. Side Effects

Common Side Effects: Headache is one of the most common side effects, which may occur in about 10 - 20% of patients. Constipation or diarrhea can also happen. Some patients may experience dizziness or light - headedness.

Less Common Side Effects: There may be mild alterations in liver function tests. In rare cases, allergic reactions such as rash, itching, or more severe anaphylactic reactions can occur.

7. Precautions and Contraindications

Drug Interactions: It can interact with other drugs metabolized by cytochrome P450 enzymes. For example, drugs that inhibit CYP1A2, CYP2D6, or CYP3A4 may increase the plasma concentration of ondansetron hydrochloride, leading to an increased risk of side effects.

Contraindications: Patients with known hypersensitivity to ondansetron hydrochloride or any of its components should not use the drug.

Overall, ondansetron hydrochloride is an important drug in the management of nausea and vomiting, playing a crucial role in improving the quality of life of patients undergoing chemotherapy, surgery, or radiation therapy.

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Basic Info

Product Name:

Ondansetron hydrochloride dihydrate

Other Name:

4H-Carbazol-4-one,1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-,hydrochloride,hydrate (1:1:2);4H-Carbazol-4-one,1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-,monohydrochloride,dihydrate;Ondansetron hydrochloride dihydrate

CAS No.:

103639-04-9

Molecular Formula:

C18H19N3O.ClH.2H2O

InChIKeys:

InChIKey=VRSLTNZJOUZKLX-UHFFFAOYSA-N

Molecular Weight:

365.85

Exact Mass:

82.053101

EC Number:

1312995-182-4

Categories:

Digestive System Drugs

Characteristics

PSA:

41.8 Å²

XLogP3:

3.80190

Appearance:

white crystal powder

Density:

1.1±0.1 g/cm3

Melting Point:

231-232 C

Boiling Point:

553.1°C at 760 mmHg

Flash Point:

144.9±5.1 °C

Refractive Index:

1.523

Water Solubility:

H2O: >5mg/mL

Storage Conditions:

−20°C

Vapor Pressure:

1.47E-12mmHg at 25°C

See More Ondansetron hydrochloride dihydrate Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Serious eye damage, Category 1

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H318 Causes serious eye damage H410 Very toxic to aquatic life with long lasting effects
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P273 Avoid release to the environment.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help. P391 Collect spillage.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Ondansetron hydrochloride dihydrate Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
Bangladesh	Ondansetron HCI	50.00 KG	Dec 11, 2025
Pakistan	Ondansetron HCL	40.00 G	Jul 4, 2025

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